IndraLab

Statements

VCP binds OTULIN. 6 / 6
2 | 3 1
reach
"K99R mutation had similar marginal effects on OTULIN or p97 interaction (XREF_FIG D)."
24726323
biogrid
No evidence text available
24726323
biogrid
No evidence text available
24726323
reach
"Therefore, the unique combination of amino acids of HOIP Lys99, Asn101, and Arg106 would specifically expand its PUB domain to interact with internal PIMs, as opposed to the PUB domains of UBXD1 or PN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24726327
sparser
"Based on the structural data showing a tight fit of the central tyrosines and the ITC measurements of the phosphorylated OTULIN-peptide, the phosphorylation of these tyrosines inhibits the interaction[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24726327
reach
"This posed the possibility for a very similar OTULIN binding mode to the HOIP PUB domain in comparison to p97 and the PNGase PUB domain.To further investigate the interaction between HOIP, OTULIN and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24726327