IndraLab

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BAP1 activates 2'-O-methyluridine. 11 / 11
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"Using BAP1‐competent UM cell lines engineered to reduce BAP1 expression through doxycycline‐induced shRNA expression, we found that reduction of BAP1 correlated with increased histone H2A ubiquitination, suggesting that in UM, BAP1 contributes to epigenetic regulation (Figure 4A)."
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"Of note, UM is driven by activating mutations in Gαq pathway, which are recurrently associated with a second mutation in BAP1 (BRCA1-associated protein 1), SF3B1 or EIF1AX (eukaryotic translation initiation factor 1A X-linked)."
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"BAP1 depletion appears to promote UM cell migration underneath the monolayer."
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"The results suggest that knowledge of mutations in BAP1 and EIF1AX can enhance prognostication of UM beyond that determined by chromosome 3 and tumor characteristics."
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"However, the molecular mechanisms through which BAP1 promotes UM metastasis is still unclear.An important open question is whether the sunlight exposure could cooperate with BAP1 inactivation in UM development and progression."
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"XREF_BIBR UM in BAP1 germ line mutants is usually diagnosed between the ages of 30 and 59 years, and is driven by inactivating mutations in the lone functional BAP1 gene, analogous to the frequent loss of chromosome 3 observed in high-risk sporadic disease."
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"In the bone, skin, and liver, UM metastasis was found to be caused by aberrant methylation of BAP1 and SF3B1."
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"BAP1 loss-of-function mutations promote the metastatic spread of UM cancers in patients XREF_BIBR, and TEM should be a rate limiting step of metastasis."
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"These studies demonstrate that BAP1 deficiency slows the proliferation of UM cells through regulation of S6 phosphorylation."
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"Nevertheless, the key node of BAP1 pathway in driving or mediating UM metastasis remains unexplored.LaFave LM et al. reported that knockout of BAP1 results in elevated transcription of EZH2 gene in acute myeloid leukemia mouse bone marrow cells and human mesothelioma cells [48]."
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"This technique has generated a new and expanded list of BAP1 targets in UM that provides important insight into metastasis pathways and identifies novel potential therapeutic targets."
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