IndraLab

Statements

BAP1 activates 2'-O-methyluridine. 7 / 7
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"XREF_BIBR UM in BAP1 germ line mutants is usually diagnosed between the ages of 30 and 59 years, and is driven by inactivating mutations in the lone functional BAP1 gene, analogous to the frequent loss of chromosome 3 observed in high-risk sporadic disease."
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"However, the molecular mechanisms through which BAP1 promotes UM metastasis is still unclear.An important open question is whether the sunlight exposure could cooperate with BAP1 inactivation in UM development and progression."
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"BAP1 loss-of-function mutations promote the metastatic spread of UM cancers in patients XREF_BIBR, and TEM should be a rate limiting step of metastasis."
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"BAP1 depletion appears to promote UM cell migration underneath the monolayer."
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"The results suggest that knowledge of mutations in BAP1 and EIF1AX can enhance prognostication of UM beyond that determined by chromosome 3 and tumor characteristics."
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"Nevertheless, the key node of BAP1 pathway in driving or mediating UM metastasis remains unexplored.LaFave LM et al. reported that knockout of BAP1 results in elevated transcription of EZH2 gene in acute myeloid leukemia mouse bone marrow cells and human mesothelioma cells [48]."
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"This technique has generated a new and expanded list of BAP1 targets in UM that provides important insight into metastasis pathways and identifies novel potential therapeutic targets."
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