IndraLab

Statements

CYLD activates IKBKE. 7 / 7
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"CYLD deficiency causes constitutive activation of TBK1 and IKKε in DCs, and the CYLD-deficient DCs and MEFs are hyper-responsive to VSV in IFNβ induction xref ."
27012466
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"Although this phenotype may involve ubiquitin dependent activation of RIG-I, CYLD also directly targets TBK1 and IKKepsilon to inhibit their ubiquitination 79."
27012466
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"Because CYLD deficiency causes constitutive activation of IKKε and TBK1, this DUB has been suggested to play an essential role in preventing the aberrant activation of these kinases during the induction of type1 interferon that occurs during viral infection ( xref )."
19489724
reach
"Genetic deficiency in the DUB CYLD causes constitutive activation of TBK1 and IKKepsilon in DCs, rendering the cells hyperresponsive to VSV induced type I IFN expression XREF_BIBR, XREF_BIBR."
27012466
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"CYLD deficiency causes constitutive activation of IKKepsilon and TBK1, which is associated with hyper-induction of IFNs in virus infected cells."
18467330
reach
"CYLD deficiency causes constitutive activation of TBK1 and IKKepsilon in DCs, and the CYLD deficient DCs and MEFs are hyper-responsive to VSV in IFNbeta induction 80."
27012466
reach
"Because CYLD deficiency causes constitutive activation of IKKepsilon and TBK1, this DUB has been suggested to play an essential role in preventing the aberrant activation of these kinases during the induction of type1 interferon that occurs during viral infection."
19489724