IndraLab

Statements

USP1 activates Ubiquitin. 4 / 4
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"Furthermore, when we depleted USP1, which has been shown to increase endogenous ubiquitin conjugated PCNA species, an increased level of ubiquitylated PCNA could be pulled down by Spartan (XREF_FIG C)."
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"Interestingly, the ubiquitin removal from both PCNA and FANCD2 and FANCI is mediated by the same deubiquitinating enzyme USP1 [86,125] and is required for successful DNA crosslink repair [126]."
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"However, it is currently unknown whether there is a functional interaction between UAF1–USP1, USP7, USP11, and ATAD5 that leads to Ub–PCNA deubiquitination.We have previously reported that ATAD5–RLC can unload mono-Ub or poly-Ub–PCNA from DNA (46)."
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"The specificity of SJB was confirmed by various experiments : first, we show that SJB potently and selectively block USP1 activity without inhibiting other DUBs (USP2/USP5/USP7/USP14/UCH37); second, SJB inhibited binding of USP1 with HA-Ub-VS probe, but it did not affect labeling of other DUBs with probe; and third, SJB inhibited USP1, but not USP2 or USP7, triggered cleavage of ubiquitin tetramer chains."
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