IndraLab

Statements

COPS5 activates MYC. 3 / 4
| 3
reach
"Inhibition of CSN5 can significantly repress multiple key oncogenic pathways in PC progression (eg, MYC, FOXM1, CTNNB1, and AUROR signaling) regardless of AR status."
34802033
reach
"However, a protein called CSN5 (also known as Jab1) that had been previously shown to posttranscriptionally promote MYC activation in breast epithelium [XREF_BIBR] was found to be overexpressed in early HCC in parallel with induction of the MYC regulated gene expression signature."
21559202
reach
"Interestingly, it has been reported that JAB1 knockdown stabilized MYC protein level, but inhibited MYC induced transcriptional activity [37], suggesting that JAB1 increased the turnover of MYC protei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23911788