IndraLab

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COPS5 activates MYC. 5 / 6
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"For example, COPS5 activates MYC by mediating the SKP1-CUL1-F-box protein complex (Lyapina et al., 2001)."
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"However, a protein called CSN5 (also known as Jab1) that had been previously shown to posttranscriptionally promote MYC activation in breast epithelium [XREF_BIBR] was found to be overexpressed in early HCC in parallel with induction of the MYC regulated gene expression signature."
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"For example, COPS5 activates MYC by mediating the SKP1-CUL1-F-box protein complex ( xref )."
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"Interestingly, it has been reported that JAB1 knockdown stabilized MYC protein level, but inhibited MYC induced transcriptional activity [37], suggesting that JAB1 increased the turnover of MYC protei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inhibition of CSN5 can significantly repress multiple key oncogenic pathways in PC progression (eg, MYC, FOXM1, CTNNB1, and AUROR signaling) regardless of AR status."
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