IndraLab

Statements

KCNH2 inhibits wave. 6 / 6
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"In addition to causing significant concentration dependent QTc prolongation, pure hERG potassium channel block (dofetilide) caused concentration dependent T wave flatness, asymmetry, and notching (see XREF_FIG for ECG examples), consistent with ECG findings from LQT2 patients (abnormal hERG potassium channel)."
25870186
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"Pure hERG block (dofetilide) and strong hERG block with lesser calcium and late sodium block (quinidine) caused substantial T wave morphology changes (P < 0.001)."
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"Hua et al XREF_BIBR showed that 6-fold overexpression of native hERG eliminates T wave alternans in isolated canine ventricular myocytes and in computer simulations."
20191107
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"Strong late sodium current and hERG block (ranolazine) still caused T wave morphology changes (P < 0.01)."
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"This study observed that pure hERG potassium channel block with dofetilide causes substantial concentration dependent T wave flatness, asymmetry, and notching, along with a decrease in the maximum magnitude of the T vector."
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"Strong calcium and hERG block (verapamil) did not cause T wave morphology changes."
25870186