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HCN1 inhibits CA1. 3 / 3
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"Furthermore, when dorsal CA1 I h was reduced by shRNA-HCN1, the CUS induced behavioral deficits were prevented."
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"9 When HCN1 protein was reduced (about 40%-50%) in dorsal CA1 region (which corresponds to the posterior hippocampus in human) in normal rats, we observed antidepressant- and anxiolytic like effects in specific behavioral tests (e.g., open-field test, elevated plus maze test, and forced swim test)."
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"Levels of NRSF and its physical binding to the hcn1 gene were augmented after SE, resulting in repression of hcn1 expression and HCN1 mediated currents (I h), and reduced I h -dependent resonance in hippocampal CA1 pyramidal cell dendrites."
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