IndraLab

Statements

EGFR phosphorylates MET. 41 / 41
| 19 19 3
reach
"The authors proposed that in tumour cells, TGFalpha mediated EGFR activation induces EGFR and c-Met interaction, detectable as co-immunoprecipitation and resulting in increased c-Met phosphorylation and signalling [XREF_BIBR]."
28536399
sparser
"We explored whether inhibition of the SFKs could block EGFR-induced c-Met phosphorylation through the use of pan-SFK inhibitors, PP2 and dasatinib."
21423210
reach
"EGFR and c-Met kinase activity is required for EGF induced c-Met phosphorylation."
24884778
reach
"We proposed that TGFalpha and the autocrine activation of its receptor, epidermal growth factor receptor (EGFR), leads to phosphorylation and activation of c-Met."
10722725
sparser
"These results show for the first time that EGFR activates MET independent of other ERBB family members, and that both wild-type and activated EGFR induce MET phosphorylation."
23794705
reach
"We have also previously demonstrated a reinforcing loop of c-Met-EGFR cross activation initiated by HGF in lung cancer, that occurs via COX-2 activation and involves direct phosphorylation of c-Met by EGFR ligands [XREF_BIBR, XREF_BIBR]."
21390244
sparser
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of HGF or another secreted factor, supporting a ligand-independent mechanism."
21423210
reach
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of hepatocyte growth factor (HGF) or another secreted factor, supporting a ligand independent mechanism."
21423210
rlimsp
"This demonstrates that a transcriptional component is required for EGFR trans-phosphorylation of c-Met and that the increase in c-Met expression is due to new c-Met transcription."
21423210
sparser
"Delayed phosphorylation of c-Met by EGFR does not require HGF and is an example of c-Met ligand-independent signaling."
21390244
sparser
"To determine if this is a general mechanism of EGFR-induced MET phosphorylation, Src inhibitors were evaluated for the ability to prevent EGFR-MET cross-talk in 32D cells."
23794705
sparser
"We found that the receptor numbers were correlated to in vitro inhibition of EGFR and c-MET receptor phosphorylation by EGFR × c-MET bispecific JNJ-61186372 ( xref )."
26260789
reach
"It has been previously reported in other model systems including human hepatocellular carcinoma cells and non small cell lung cancer that EGFR activation contributes to c-Met phosphorylation."
21622718
reach
"Delayed phosphorylation of c-Met by EGFR does not require HGF and is an example of c-Met ligand independent signaling."
21390244
sparser
"Conversely, in H292 wt-EGFR NSCLC cells, EGFR promotes the tyrosine phosphorylation of MET."
37368466
reach
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of HGF or another secreted factor, supporting a ligand independent mechanism."
21423210
sparser
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of hepatocyte growth factor (HGF) or another secreted factor, supporting a ligand-independent mechanism."
21423210
sparser
"Cross-talk between EGFR and c-Met in lung cancer, including EGFR-dependent phosphorylation and activation of c-Met through EGFR ligands, has been widely reported. xref Because of this cross-talk and link between EGFR TKI resistance and c-Met activation, simultaneous targeting of these 2 pathways holds promise. xref Multiple studies have highlighted the use of EGFR and c-Met combination treatments, as well as single, dual targeting therapeutics. xref In response to this need, we designed JNJ-61186372 as a bispecific antibody to dually target EGFR and c-Met. xref "
27786612
reach
"EGFR activation stimulates c-MET phosphorylation and activation."
29063069
reach
"EGFR activation leads to c-MET phosphorylation and activation."
26391154
reach
"Phosphorylation of hepatocyte growth factor receptor and epidermal growth factor receptor of human hepatocytes can be maintained in a (3D) collagen sandwich culture system."
15130610
sparser
"Similar observations have been made with other cell types ( xref ; xref ); these and other published data support the idea that EGFR may directly phosphorylate MET ( xref ; xref )."
20154724
sparser
"HGF Autocrine Signaling is not Responsible for EGFR-induced c-Met Phosphorylation."
21423210
rlimsp
"Delayed phosphorylation of c-Met by EGFR does not require HGF and is an example of c-Met ligand-independent signaling."
21390244
sparser
"In addition to regulating MET protein stability, it is possible that EGFR activates MET through signaling proteins such as Src, which acts as an intermediary in EGFR-induced MET phosphorylation of the EGFR wild-type NSCLC cell line, 201T ( xref )."
23794705
sparser
"Despite these increasing reports of EGFR –c-Met lateral signaling, the underlying mechanism of EGFR-induced c-Met phosphorylation is not well understood, and the extent of involvement of c-Met in carrying out EGFR-initiated phenotypes has not been well documented."
21423210
reach
"Other studies in NSCLC suggest EGFR signaling through MAPK is sufficient to induce c-Met phosphorylation, leading to enhanced migration, invasion, and metastasis [XREF_BIBR]."
26000702
reach
"This demonstrates that a transcriptional component is required for EGFR trans-phosphorylation of c-Met and that the increase in c-Met expression is due to new c-Met transcription."
21423210
sparser
"EGF-induced MET phosphorylation could occur through direct phosphorylation of MET by EGFR, EGF-dependent activation of MET autophosphorylation, or another intermediary kinase."
23794705
reach
"A separate study showed that activated EGFR is able to phosphorylate c-Met indirectly through Src [XREF_BIBR]."
25784650
reach
"Several groups have investigated the molecular mechanisms underlying the crosstalk between EGFR and c-Met, and it has become apparent that several partner proteins can affect EGFR mediated phosphorylation of c-Met, including Src, MAPK and beta1 integrins [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28536399
reach
"It has been demonstrated that EGFR activation contributes to c-Met tyrosine phosphorylation in a variety of cell models, with varying kinetic parameters Since NSCLC commonly express both receptors, we examined whether EGFR ligands induce c-Met phosphorylation in human NSCLC cell lines."
21423210
reach
"Phosphorylation of c-Met by TGF-alpha and EGFR (receptor of TGFalpha) was found in several epithelial derived tumor cell lines such as human hepatoma cell lines and epidermoid carcinoma cell line, and subsequently leading to its activation."
23320251
sparser
"MAPK appears to further enhance EGFR-dependent phosphorylation of MET ( xref )."
32646879
sparser
"These results demonstrate that HGF autocrine signaling is not responsible for the EGFR-induced c-Met phosphorylation that we observed and is consistent with what we reported previously in regards to HGF paracrine signaling in HNSCC ( xref )."
21622718
rlimsp
"Gene transcription is required for delayed c-Met activation; however, phosphorylation of c-Met by EGFR occurs without production of hepatocyte growth factor (HGF) or another secreted factor, supporting a ligand-independent mechanism."
21423210
sparser
"A separate study showed that activated EGFR is able to phosphorylate c-Met indirectly through Src [ xref ]."
25784650
reach
"For instance, EGFR interacts with c-Met, and the activation of EGFR promotes the phosphorylation of c-Met XREF_BIBR - XREF_BIBR."
29449529
sparser
"We found that MAP kinase signaling correlated with higher ERBB-driven MET phosphorylation and was required for EGFR-dependent MET activation in cells with both wild-type and mutant EGFR ( xref and xref )."
23794705
reach
"VK3 induced phosphorylation of hepatocyte growth factor receptor (c-met), epidermal growth factor receptor (EGFR), or external signal regulated kinase (ERK), which increased progressively to a maximum level at 30 minutes, in a dose dependent manner and occurred at growth inhibitory concentrations."
11267961
sparser
"ERBB3 enhances EGFR induced MET phosphorylation."
23794705