IndraLab
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"No evidence was presented to support TRIM25 or USP21 mediated GLTSCR2 removal of K63-linked polyubiquitin chains from RIG-I.In this work, we presented evidence that viral infection induced translocation of GLTSCR2 from nucleus to cytoplasm, and cytoplasmic translocation enabled GLTSCR2 to effectively attenuate IFN-β and support viral replication; however, viral infection did not result in elevating GLTSCR2 in cells."