IndraLab

Statements

CYLD binds MAP3K7. 12 / 13
2 | 6 4
reach
"Finally, we showed that CYLD interacts with and deubiquitinates TAK1 to negatively regulate the activation of the downstream MKK3/6-p 38alpha/beta pathway."
18332137
sparser
"Mechanistically, CYLD interacts directly with the kinase TAK1 and removes its K63-linked polyubiquitin chain, which blocks downstream activation of the JNK-p38 cascades."
29291351
reach
"Koga et al. had reported that CYLD interacted with and deubiquitinates TAK1 by negatively regulating the activation of the downstream MKK3/6-p 38alpha/beta pathway to resist the infection of gram positive bacterium Streptococcus pneumonia [XREF_BIBR]."
27738385
sparser
"In our opinion, a good explanation for this additive effect on prognosis is that this combined score better reflects the overall activity of the Cyld-Tak1 axis and that higher activity is correlated with worse prognosis."
35053591
reach
"CYLD interacts with and negatively regulates TAK1, reducing TAK1 mediated stimulation of IKK and hence activation of NFkappaB."
21552290
sparser
"Multivariate analysis, including the combined Tak1-Cyld classes, illustrated that high nuclear Tak1 and low nuclear Cyld expression clearly represents a strong and statistically independent prognostic factor."
35053591
reach
"This hypothesis is supported by a previous study in T cells showing that CYLD physically interacts with TAK1 and inhibits its ubiquitination and catalytic activity following T cell receptor stimulation."
21931165
biogrid
No evidence text available
18332137
reach
"We show in this study that CYLD physically interacts with Tak1 and inhibits its ubiquitination and catalytic activity."
17548520
reach
"Interestingly, endogenous CYLD and Tak1 indeed formed a complex in T cells, which was readily detected by co-immunoprecipitation (IP) assays using the anti-CYLD antibody (XREF_FIG)."
17548520
biogrid
No evidence text available
27591049
sparser
"This hypothesis is supported by a previous study in T cells showing that CYLD physically interacts with TAK1 and inhibits its ubiquitination and catalytic activity following T cell receptor stimulation ( xref )."
21931165