IndraLab

Statements

DUB inhibitor activates UCHL5. 3 / 3
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"We found that the p300-specific DUB inhibitor, bAP-15 reduces p300 protein stability by targeting ubiquitin-specific protease 14 (USP14) and ubiquitin C-terminal hydrolase L5 (UCHL5)."
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"b-AP15 is a DUB inhibitor that selectively blocks deubiquitylating activity of UCHL5 and has been investigated in a few animal experiments 49, 50."
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"Instead, it was found to be a partially selective DUB inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14 and UCH37, which are known to regulate survival protein stability and 26S proteasome function [XREF_BIBR]."
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