IndraLab

Statements

CYLD decreases the amount of Cyclin. 3 / 3
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reach
"Indeed, CYLD is upregulated in injured carotid arteries of rats, reduces cyclin D1 levels, and is capable of suppressing vascular lesion formation."
25342597
reach
"In agreement with the mechanism in keratinocytes, CYLD markedly reduced expression of Cyclin D1 (XREF_FIG), cyclin D1 promoter activity (XREF_FIG), and BCL-3 recruitment to the cyclin D1 promoter in a complex with p50 or p52 (XREF_FIG, left) as compared with cells transduced with viral vectors carrying a catalytically inactive mutant of CYLD (C/S-CYLD), a GFP expression cassette or noninfected cells."
19124656
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"Also supporting this line of evidence is the finding that the tumor suppressor CYLD blocks cyclin D1 expression by inhibiting Bcl-3 signaling [XREF_BIBR]."
20731879