IndraLab

Statements

AKT1 phosphorylates RPS6KB1. 8 / 8
| 6 2
reach
"Further studies demonstrated that a constitutively-active Akt1 (ca-Akt1) restored Akt and p70S6K1 phosphorylation in GNE-477-treated RCC1 cells (XREF_FIG)."
32421688
rlimsp
"In conclusion, the FFAR1 promoted airway smooth muscle cell proliferation and p70S6K phosphorylation through MEK/ERK and PI3K/Akt signaling pathways."
29097424
reach
"In Figures XREF_FIG, application of the phosphoinositide 3-kinase (PI 3-K) inhibitor LY294002 (10 muM) during treatment with either EPO (10 ng/ml) or Wnt1 (100 ng/ml) prevented EPO or Wnt1 from phosphorylating mTOR and p70S6K, illustrating that the PI 3-K and Akt1 pathways are necessary for EPO or Wnt1 to phosphorylate mTOR and p70S6K."
22388478
reach
"Furthermore, upstream overexpression or knockdown of Akt2 or Akt2 phosphorylation inhibition, rather than Akt1 or Akt3, resulted in striking hyperphosphorylation or dephosphorylation of mTOR, p70S6K and rpS6 (all P < 0.05), without any change in total proteins expressions."
26490682
reach
"P70S6K can be activated in cells by the overexpression of activated PKB [50,51], but PKBalpha does not phosphorylate p70S6K in vitro [47]."
9838087
reach
"[21, 22] Inhibition of MERTK by shRNA prevented the Gas6-induced increase of pAkt, pERK1/2, and pSTAT6, decreased basal phosphorylation of Akt, mTOR, and p70S6 kinase, increased PARP cleavage, and decreased CDC42 activity."
23833304
rlimsp
"Constitutively active v-AKT highly phosphorylated p70S6K, which was totally inhibited by rapamycin."
10849422
reach
"However, it has also been reported that knockdown of Akt1, 2, and 3 in bladder cancer cell lines specifically decreases S6K1 phosphorylation but not 4EBP1 phosphorylation level."
32286710