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AKT1 phosphorylates RPS6KB1. 8 / 8
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"In Figures XREF_FIG, application of the phosphoinositide 3-kinase (PI 3-K) inhibitor LY294002 (10 muM) during treatment with either EPO (10 ng/ml) or Wnt1 (100 ng/ml) prevented EPO or Wnt1 from phosphorylating mTOR and p70S6K, illustrating that the PI 3-K and Akt1 pathways are necessary for EPO or Wnt1 to phosphorylate mTOR and p70S6K."
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"[21, 22] Inhibition of MERTK by shRNA prevented the Gas6-induced increase of pAkt, pERK1/2, and pSTAT6, decreased basal phosphorylation of Akt, mTOR, and p70S6 kinase, increased PARP cleavage, and decreased CDC42 activity."
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"However, it has also been reported that knockdown of Akt1, 2, and 3 in bladder cancer cell lines specifically decreases S6K1 phosphorylation but not 4EBP1 phosphorylation level."
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"Further studies demonstrated that a constitutively-active Akt1 (ca-Akt1) restored Akt and p70S6K1 phosphorylation in GNE-477-treated RCC1 cells (XREF_FIG)."
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"Expression of myr-Akt induced p70S6K phosphorylation in HOS cells expressing shSET to the same level as in shNT-expressing HOS cells (Fig. S3F)."
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"P70S6K can be activated in cells by the overexpression of activated PKB [50,51], but PKBalpha does not phosphorylate p70S6K in vitro [47]."
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"These results implied that TIMM13 is indeed important for Akt-mTOR cascade activation in OS cells.Next, the constitutively-active Akt1 (caAkt1, S473D)-expressing adenovirus [26, 44] was transduced to koTIMM13 pOS-1 cells, restoring Akt and S6K1 phosphorylation (Fig. 6C)."
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"Furthermore, upstream overexpression or knockdown of Akt2 or Akt2 phosphorylation inhibition, rather than Akt1 or Akt3, resulted in striking hyperphosphorylation or dephosphorylation of mTOR, p70S6K and rpS6 (all P < 0.05), without any change in total proteins expressions."
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