IndraLab
Statements
sparser
"Future work must determine how FMRP-BK channel interaction may contribute to alterations in excitatory-excitatory and/or excitatory-inhibitory connectivity observed in the hippocampus and cortex of FMR1 KO mice that has been shown to depend on pre-synaptic loss of FMRP as well (Hanson and Madison, xref ; Patel et al., xref )."
sparser
"These results suggest a model in which the effects of R138Q mutation are caused by disruption of FMRP’s protein-protein interactions, including FMRP-BK channel interactions, which are important in regulating neuronal excitability and glutamate release, while retaining translational regulation functions of FMRP."