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USP10 deubiquitinates YAP1. 15 / 15
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"Here, the synergistical upregulation of USP10 and YAP1 in PAAD indicated that USP10 possibly deubiquitinates and stabilizes YAP1 to affect PAAD progression."
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"Co‐IP outcomes demonstrated that downregulation of USP10 rose the ubiquitination of YAP1, and conversely, upregulation of USP10 decreased the ubiquitination of YAP1 (Figure 8I)."
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"Liu et al. demonstrated that ubiquitin-specific peptidase 10 (USP10) inhibited YAP1 ubiquitination and degradation to promote cysteine rich angiogenic inducer 61 (Cyr61) expression, which induced immune escape and promoted the growth and metastasis of pancreatic adenocarcinoma (PAAD)."
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"In conclusion, this work demonstrates that USP10 inhibits YAP1 ubiquitination and degradation to promote Cyr61 expression, which induces immune escape and promotes growth and metastasis of PAAD."
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"Another three DUBs, ubiquitin carboxyl-terminal hydrolase 10 (USP10), otubain-2 (OTUB2) and ubiquitin carboxyl-terminal hydrolase 47 (USP47) deubiquitinate YAP/TAZ, playing important roles in hepatocellular carcinoma, breast cancer and colorectal cancer, respectively21 32 33."
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"USP10 depletion enhanced the polyubiquitination of YAP/TAZ, promoted their proteasomal degradation, and ultimately arrested the proliferation of hepatocellular carcinoma in vitro and in vivo [38]."
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"In the context of HCC, USP10 promotes HCC cell proliferation and metastasis by deubiquitinating and stabilizing YAP and TAZ, the effector transcription factors of the Hippo signaling pathway, and SMAD4, the major signaling effector of TGFβ signaling [39,40,]."
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"USP10 enhances proliferation of HCC by stabilizing and deubiquitinating YAP [ 33 ]."
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"Hong Zhu et al. revealed that USP10 promotes the proliferation of hepatocellular carcinoma by deubiquitinating and stabilizing YAP/TAZ [ 8 ]."
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"USP10 can deubiquitinate and stabilize YAP1, and its inhibitor Wu-5 was found to potently suppress leukemia [139, 140], exhibiting its potential for eliminating undruggable oncoproteins to restore immunosurveillance."
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"Previous studies have reported that USP10 promotes cisplatin resistance by deubiquitinating HDAC6 in non-small cell lung cancer [44], and promotes tumor growth and proliferation by deubiquitinating TAZ/YAP in liver cancer [45]."
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"Deubiquitylation of YAP by USP10 mediates the aberrant activation of the Hippo pathway and progression of hepatocellular carcinoma [256]."
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"Depletion of USP10 enhances polyubiquitination of YAP/TAZ, promotes their proteasomal degradation, and ultimately arrests the proliferation of hepatocellular carcinoma [24]."
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"Furthermore, USP10 desensitizes pancreatic ductal adenocarcinoma (PDAC) cells to NK cell-mediated cytotoxicity by deubiquitinating yes-associated protein 1 (YAP1, a core component of Hippo signaling) to transcriptionally upregulate both PD-L1 and galectin-9 (Gal-9) [23]."
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"The deubiquitination enzymes ubiquitin specific peptidase 10 (USP10), ubiquitin specific peptidase 47 (USP47), OUT deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2), and eukaryotic translation initiation factor 3 subunit H (EIF3H) deubiquitinated YAP1 to maintain protein stability [61, 62, 63]."
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