IndraLab

Statements

Imipramine inhibits KCNH1. 12 / 12
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"It was observed that all three doses of imipramine significantly reduced Eag1 currents and conductivity compared with the control."
34729805
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"Thus, we wondered whether two drugs that are widely used to inhibit Eag1, namely, astemizole and imipramine, might affect the cell proliferation of primary retinoblastoma cultures."
31973216
dgi
No evidence text available
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"First, Eag1 blockers imipramine and astemizole were shown to reduce tumor cell growth."
27698831
ctd
No evidence text available
18497958
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"HEag1 inhibition by the antihistamine astemizole, the tricyclic antidepressant imipramine or hEag1 specific monoclonal antibodies reduces tumor cell proliferation in vitro and in vivo [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
20105281
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"HEag1 channels recorded in these conditions were blocked by bath applications of imipramine (XREF_FIG A) and astemizole (XREF_FIG B)."
15365094
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"The Eag blocker imipramine at 50 muM significantly inhibited the proliferation of SK-OV-3 cell lines at 72 hours of culture (P < 0.001; Figure XREF_FIG) while clofilium (100-3300 nM) did not show any effect on proliferation at any of the time points tested."
21392380
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"Inhibition of hEag1 by imipramine and mAb56 reduced the migration of HEL and PLB-985 cells up to 65%, indicating an implication of the channel activity in this phenomenon."
20105281
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"Dose dependent Inhibition of hEag1 Currents by Imipramine and Astemizole."
15365094
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"Both Eag blockers imipramine 50 muM and clofilum 3300 etaM demonstrated no effect on the G0/G1, S or G2M phases of the cell cycle."
21392380
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"Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide."
16949586