IndraLab

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NGF bound to NTRK1 activates NTRK1. 9 / 9
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"In addition, the NGF induced REM sleep like state is mediated by tropomyosin related kinase A (trkA) which binds with high affinity to NGF and, to a lesser extent, to neurotrophin-3."
21840513
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"NGF binding to TrkA causes TrkA dimerization, followed by autophosphorylation of multiple tyrosine residues located within the intracellular domain of TrkA."
20059802
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"To exert its effects, NGF selectively binds to its high affinity TrkA receptors, located at the plasma membrane of responsive cells, which causes TrkA receptors to form homodimers and activates the intrinsic tyrosine kinase activity of the receptor resulting in autophosphorylation of receptor subunits."
19596387
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"NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20]."
21138586
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25410238
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"NGF binding to TrkA upregulates TrkA receptors (Kumar and Mahal, 2012), glutamatergic receptors (Pezet and McMahon, 2006), and substance P/CGRP through the PKCε pathway (Kallakuri et al., 2004; Kobayashi et al., 2004; Kumar and Mahal, 2012)."
29523370
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"As we demonstrated that hfNBMs express the TrkA receptor, we next questioned whether the formation of a NGF and TrkA complex activated a functional TrkA signaling pathway and assessed the phosphorylation of TrkA (pTrkA) and the activation of TrkA down-stream effectors (p-ERK1/2, p-CREB or c-fos)."
29163051
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"NGF binding to TrkA activates the tyrosine kinase domain of TrkA, which triggers pathways involving ERK1/2, Akt, and PLCγ (Chao et al. 2006)."
24633937
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"NGF binds to TrkA, activates the intrinsic kinase activity of TrkA, and promotes the differentiation of pheochromocytoma (PC12) cells into sympathetic like neurons."
10187854