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NGF bound to NTRK1 activates NTRK1. 17 / 17
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"The binding of NGF to TrkA induces its dimerization and transphosphorylation at tyrosine residues located in the TrkA cytoplasmic domains [34]."
36768281
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"As we demonstrated that hfNBMs express the TrkA receptor, we next questioned whether the formation of a NGF and TrkA complex activated a functional TrkA signaling pathway and assessed the phosphorylation of TrkA (pTrkA) and the activation of TrkA down-stream effectors (p-ERK1/2, p-CREB or c-fos)."
29163051
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"Binding of NGF to TrkA leads to the formation of NGF–TrkA dimer complex [33,42] ."
15533302
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"To exert its effects, NGF selectively binds to its high affinity TrkA receptors, located at the plasma membrane of responsive cells, which causes TrkA receptors to form homodimers and activates the intrinsic tyrosine kinase activity of the receptor resulting in autophosphorylation of receptor subunits."
19596387
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"NGF binds to TrkA, activates the intrinsic kinase activity of TrkA, and promotes the differentiation of pheochromocytoma (PC12) cells into sympathetic like neurons."
10187854
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"For example, PI3K and Erk1/2 have together been shown to be necessary for neurite outgrowth when activated by NGF binding to TrkA at the presynaptic nerve terminal, whereas activation of PI3K within t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24709025
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"NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20]."
21138586
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"They found that nerve NGF binding to TrkA induces Neu1 sialidase activation in live primary neurons and TrkA- and TrkB-expressing cell lines."
39128726
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"Nerve growth factor (NGF) binds to its receptor tropomyosin receptor kinase A (TrkA), which activates dimerization and auto-phosphorylation of TrkA."
38213543
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"NGF binding to TrkA activates the tyrosine kinase domain of TrkA, which triggers pathways involving ERK1/2, Akt, and PLCγ (Chao et al. 2006)."
24633937
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"NGF binding to TrkA causes TrkA dimerization, followed by autophosphorylation of multiple tyrosine residues located within the intracellular domain of TrkA."
20059802
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25410238
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"The hypothesis is that selective TrkA inhibition in the periphery will block the formation of NGF/TrkA complex, while the inhibition of Rab7 will disrupt the NGF/TrkA long-range retrograde signaling, hence affecting the alteration in DRG cell bodies."
38892241
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"This finding suggests that TrkA trafficking in BFCNs is similar to DRGs, where NGF-bound TrkA promotes the recruitment of additional TrkA receptors to axon terminals in a positive feedback loop ( Yama[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31574357
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"NGF binding to TrkA upregulates TrkA receptors (Kumar and Mahal, 2012), glutamatergic receptors (Pezet and McMahon, 2006), and substance P/CGRP through the PKCε pathway (Kallakuri et al., 2004; Kobayashi et al., 2004; Kumar and Mahal, 2012)."
29523370
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"Binding of NGF to its receptor TrkA leads to the activation of the Trk signaling pathway, which can rapidly increase the activity or expression of ion channels, resulting in neuron depolarization and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37392821
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"In addition, the NGF induced REM sleep like state is mediated by tropomyosin related kinase A (trkA) which binds with high affinity to NGF and, to a lesser extent, to neurotrophin-3."
21840513