IndraLab

Statements

STAMBP activates EGFR. 13 / 15
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"Importantly, increased STAMBP promoted the stabilization of EGFR, suggesting STAMBP as a novel target for LUAD therapy [168]."
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"Its homologue STAMBP (or AMSH) is known to participate in endosomal sorting of receptors and membrane proteins [XREF_BIBR], e.g., STAMBP knockdown enhancing EGFR degradation."
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"13 Although AMSH depletion does not impair epidermal growth factor receptor degradation, 14,15 inhibition of its recruitment to endosomes by ESCRT-III charged MVB protein (CHMP) 3 impairs epidermal gr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In other studies, both AMSH XREF_BIBR, XREF_BIBR and UBPY XREF_BIBR, XREF_BIBR, XREF_BIBR have been reported to increase EGFR down-regulation."
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"Mechanistically, increased STAMBP expression promoted the stabilization of Epidermal growth factor receptor (EGFR), whereas STAMBP knockdown induced the degradation of EGFR."
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"However, other studies have shown that BC-1471 exerted no inhibitory effect on STAMBP-mediated ubiquitination deconjugation or STAMBP-mediated EGFR stabilization in vitro ."
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"STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR and MAPK signaling pathway."
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"[1617] Remarkably, a second Hrs interacting protein is AMSH, a JAMM domain DUB,[18] the inhibition of which results in the accumulation of endosomal Ub and promotes EGFR endocytosis, thereby accelerating EGFR downregulation."
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"AMSH rescues EGFR from sorting to MVBs and consequently degradation, by removing Ub from the receptor at early stages of endosomal sorting, thus promoting its recycling [64,67,68] ."
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"Consistently, knockdown of endogenous AMSH or overexpression of catalytically inactive AMSH mutants has been shown to promote the lysosomal degradation of epidermal growth factor receptor (EGFR) as well as other cell surface receptors [XREF_BIBR - XREF_BIBR]."
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"The recent studies validated these hypotheses: WWP1-induced EGFR ubiquitination was found to be a decisive signal for EGFR recycling (30); meanwhile, the overexpression of STAMBP can promote the stabilization of EGFR, and promote tumor progression (31)."
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"Similarly, endosomal deubiquitinase AMSH (Associated Molecule with the SH3-domain of STAM) has been shown to antagonize the ubiquitin dependent lysosomal degradation of EGFR by trimming the K63 linked ubiquitin chains [XREF_BIBR] while other studies have shown this DUB to be required for MVB dependent EGFR degradation [XREF_BIBR, XREF_BIBR]."
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"Nevertheless, both AMSH [31, 34, 35] and UBPY [32, 33, 36-38] have been reported to increase EGFR down-regulation."
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