IndraLab

Statements

UCHL1 activates CTNNB1. 6 / 14
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"These observations imply that UCHL1 may contribute to CRC progression by activating the beta-catenin and TCF pathway through its deubi quitinating activity."
22641175
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"UCHL1 up-regulates beta-catenin signaling and possibly promotes invasion of both Salmonella and Listeria by modulating actin dynamics in the host cell."
20977569
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"Aberrant expression of UCHL1 in pediatric high-grade gliomas may promote cell invasion, transformation, and self-renewal properties, at least in part, by modulating Wnt and Beta catenin activity."
28472177
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"In contrast, other studies have documented that UCH-L1 up-regulates beta-catenin and TCF via a positive feedback mechanism or exerts anti-apoptotic and growth stimulating effects, supporting an oncogenic potential of UCH-L1 [XREF_BIBR, XREF_BIBR]."
19945429
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"While UCH-L1 has been shown to inhibit alpha 2 -adrenergic receptor (AR) agonist mediated activation of ERK via a direct association with alpha 2A -AR receptor implicating a role of UCH-L1 in neuro-protection XREF_BIBR, it has also been documented that UCH-L1 up-regulates oncogenic beta-catenin and TCF and Akt signaling to induce tumor cell proliferation and migration contributing to tumor progression XREF_BIBR, XREF_BIBR."
24732420
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"Of note, UCHL1 also promotes the activity of the WNT pathway by stabilizing beta-catenin."
28688920