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"The online version of this article includes the following figure supplement (s) for figure 5 : Distributions of P IRF9 and P USP18 activation times in cells treated with different cell cycle perturbations.Cell cycle dependent USP18 upregulation determined by the FUCCI reporter.ISG promoters contain a wide range of CpG site numbers and methylation levels.Distributions of P IRF9 and P USP18 activation times in cells treated with decitabine.The effect of decitabine on cell cycle.Stochastic simulations with the cell-cycle gated feedback control reproduced single-cell responses to IFN pretreatments with different durations."