IndraLab

Statements

PCMT1 methylates TP53 at position 29. 4 / 4
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reach
"PIMT methylates asparagine residues 29 and 30 of p53."
22735455
reach
"We show that asparagine residues 29 and 30 of p53 are methylated by PIMT in vivo and in vitro."
22735455
reach
"To confirm that PIMT methylates p53 at isoaspartate residues 29 and 30, we synthesized peptides consisting of amino acids 22-40 of p53, in which asparagines 29 and 30 were replaced with isoaspartates (N29IsoD, N30IsoD and N29,30 IsoD)."
22735455
reach
"We also find that PIMT methylates p53 at isoaspartate residues 29 and 30, which is required to negatively regulate the p53 activity."
22735455