IndraLab

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USP44 deubiquitinates CDC20. 14 / 14
1 | 13
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"Moreover, Usp44, a ubiquitin isopeptidase, has been proposed to prevent the autoubiquitination of Cdc20 and maintain the Mad2-Cdc20 interaction during checkpoint activation."
21439394
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"USP44 knockdown increased Cdc20 polyubiquitination and centrosomal Cdc20-APC activity in neurons, and correspondingly promoted the elaboration of dendrites."
20195072
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"Knockdown of USP44 in neurons dramatically increased the polyubiquitination of Cdc20 and centrosomal Cdc20-APC activity, confirming that endogenous USP44 deubiquitinates Cdc20 in neurons (XREF_FIG)."
19167333
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"We have previously shown that USP44 deubiquitinates CDC20 to negatively regulate the anaphase promoting complex during the spindle checkpoint."
19615732
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"USP44 deubiquitinates the APC coactivator Cdc20 both in vitro and in vivo, and thereby directly counteracts the APC driven disassembly of Mad2-Cdc20 complexes (discussed in an accompanying paper)."
17443180
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"Conversely, the deubiquitinating enzyme USP44 deubiquitinates Cdc20 and drives the assembly of the inhibitory SAC complexes."
18645024
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"USP44 deubiquitinates Cdc20 and enables the stabilization of the inactive complex MAD2, CDC20, and APC/C [XREF_BIBR]."
23246971
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"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."
33643919
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"This study indicates that USP44 reduces Cdc20 autoubiquitination and protects the Mad2-Cdc20-containing checkpoint complexes from disassembly, although it remains to be determined whether USP44 also directly deubiquitinates mitotic APC/C substrates and prevents their degradation."
17650307
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"For example, USP44 directly deubiquitinates CDC20 and counteracts the APC driven disassembly of the Mad2 and CDC20 complex, which regulates the proper mitotic timing and the spindle checkpoint function 3."
29449677
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"USP44 deubiquitinates the Cdc20 and prevents the APC driven disassembly of Mad2 and Cdc20 complex [XREF_BIBR]."
23151139
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"Interestingly, USP44 (ubiquitin specific protease 44) deubiquitinated Cdc20 and blocked premature activation of APC via stabilization of the APC-inhibitory Mad2 and Cdc20 complex."
25850036
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"Usp44, however, counteracts the activity of the APC/C by deubiquitinating Cdc20, thereby preventing premature Mad2-dissociation and SAC silencing"
28188342
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"Recombinant USP44 directly deubiquitinates Cdc20 in vitro [XREF_BIBR]."
17650307