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USP44 deubiquitinates CDC20. 17 / 18
1 | 17
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"We have previously shown that USP44 deubiquitinates CDC20 to negatively regulate the anaphase promoting complex during the spindle checkpoint."
19615732
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"Conversely, USP44, a deubiquitinating enzyme, mediates the deubiquitination of CDC20 thus preventing premature anaphase onset ( Hao et al., 2012; Reddy et al., 2007; Williamson et al., 2011 ) ( Fig. 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24361302
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"USP44 (ubiquitin-specific protease 44) deubiquitinates CDC20 and blocks premature activation of APC by stabilizing the APC-inhibitory Mad2-CDC20 complex (21)."
35722431
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"USP44 knockdown increased Cdc20 polyubiquitination and centrosomal Cdc20-APC activity in neurons, and correspondingly promoted the elaboration of dendrites."
20195072
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"Since the H2Bub1 editor USP44 was reported to regulate anaphase initiation by deubiquitylating the APC coactivator Cdc20 [102] , it is tempting to speculate that USP44 may alter the dynamic recruitmen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24412854
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"Moreover, Usp44, a ubiquitin isopeptidase, has been proposed to prevent the autoubiquitination of Cdc20 and maintain the Mad2-Cdc20 interaction during checkpoint activation."
21439394
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"USP44 deubiquitinates the Cdc20 and prevents the APC driven disassembly of Mad2 and Cdc20 complex [XREF_BIBR]."
23151139
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"USP44 deubiquitinates the APC coactivator Cdc20 both in vitro and in vivo, and thereby directly counteracts the APC driven disassembly of Mad2-Cdc20 complexes (discussed in an accompanying paper)."
17443180
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"USP44 deubiquitinates Cdc20 and enables the stabilization of the inactive complex MAD2, CDC20, and APC/C [XREF_BIBR]."
23246971
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"Recombinant USP44 directly deubiquitinates Cdc20 in vitro [XREF_BIBR]."
17650307
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"This study indicates that USP44 reduces Cdc20 autoubiquitination and protects the Mad2-Cdc20-containing checkpoint complexes from disassembly, although it remains to be determined whether USP44 also directly deubiquitinates mitotic APC/C substrates and prevents their degradation."
17650307
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"Interestingly, USP44 (ubiquitin specific protease 44) deubiquitinated Cdc20 and blocked premature activation of APC via stabilization of the APC-inhibitory Mad2 and Cdc20 complex."
25850036
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"For example, USP44 directly deubiquitinates CDC20 and counteracts the APC driven disassembly of the Mad2 and CDC20 complex, which regulates the proper mitotic timing and the spindle checkpoint function 3."
29449677
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"Conversely, the deubiquitinating enzyme USP44 deubiquitinates Cdc20 and drives the assembly of the inhibitory SAC complexes."
18645024
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"Knockdown of USP44 in neurons dramatically increased the polyubiquitination of Cdc20 and centrosomal Cdc20-APC activity, confirming that endogenous USP44 deubiquitinates Cdc20 in neurons (XREF_FIG)."
19167333
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"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."
33643919
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"It has been reported that p38 signaling is critical for CDC20 proteolysis via CDH1-independent APC/C ubiquitination ( Yen and Yang, 2010 ); CDC20 is deubiquitinated by USP44, leading to stabilization [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29719258