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IFNA increases the amount of USP18. 11 / 11
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"Untreated INS-1E cells showed low USP18 mRNA expression, but IFNalpha upregulated USP18 expression from 2 to 24h (XREF_FIG)."
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"IFN-alpha, LPS, and TNF-alpha do not induce type 1 and 2 IFNs in primary murine hepatocytes but do induce USP18 expression."
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"Although IL-17A treatment alone didn’t significantly change the expression of USP18, IL-17A pretreatment could further enhance IFN-α-induced expression of USP18."
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"XREF_BIBR, XREF_BIBR We presently show that IFNalpha and dsRNA induce USP18 expression in human islets, primary rat beta cells and INS-1E cells, supporting its role in IFN related signaling pathways and antiviral responses in pancreatic beta cells."
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"Table: IFNA treatment"
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"We observed that neither IFN-α, LPS, nor TNF-α induce much, if any, hepatocyte expression of IFN-α or IFN-γ, although the same doses induce strong expression of USP18 (Fig. 5)."
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"In contrast to IFN-l treatment, IFN-a treatment of this clone failed to induce the expression of the IFN-stimulated genes, Oasl2 ( Fig. 2A) and Usp18 (Fig. 2B) , and to protect against infection with TM967, a TMEV derivative expressing mCherry (Fig. 2C) ."
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"Thus, the induction of ISGs by LPS and TNF-α is very unlikely to reflect the induction of hepatocyte type 1 or type 2 IFN, which suggests that the observed USP18 induction is not due to type 1 or type 2 IFN secretion and autocrine stimulation of the IFN-α receptor.We then assessed whether tissue-wide hepatic inflammatory stress increases liver USP18 expression, as an in vivo confirmation of our in vitro findings."
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"We indeed demonstrated that both concentrations of IFN-alpha (500 and 5000 pg/mL) significantly increased mRNA gene expression of STAT1 (fold change [fc] = 2.7 and 3.1, respectively), ISG15 (fc = 2.1 and 3.3), and USP18 (fc = 2.1 and 3.4) (XREF_FIG)."
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"In contrast to IFN-λ treatment, IFN-α treatment of this clone failed to induce the expression of the IFN-stimulated genes, Oasl2 (Fig. 2A) and Usp18 (Fig. 2B), and to protect against infection with TM967, a TMEV derivative expressing mCherry (Fig. 2C)."
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"Table 3. Genes on chromosome 22 exhibiting IFN-sensitive expression changes"
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