IndraLab

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IFNA increases the amount of USP18. 6 / 8
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"In contrast to IFN-λ treatment, IFN-α treatment of this clone failed to induce the expression of the IFN-stimulated genes, Oasl2 (Fig. 2A) and Usp18 (Fig. 2B), and to protect against infection with TM967, a TMEV derivative expressing mCherry (Fig. 2C)."
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"IFN-alpha, LPS, and TNF-alpha do not induce type 1 and 2 IFNs in primary murine hepatocytes but do induce USP18 expression."
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"We indeed demonstrated that both concentrations of IFN-alpha (500 and 5000 pg/mL) significantly increased mRNA gene expression of STAT1 (fold change [fc] = 2.7 and 3.1, respectively), ISG15 (fc = 2.1 and 3.3), and USP18 (fc = 2.1 and 3.4) (XREF_FIG)."
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"Untreated INS-1E cells showed low USP18 mRNA expression, but IFNalpha upregulated USP18 expression from 2 to 24h (XREF_FIG)."
23152055
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"XREF_BIBR, XREF_BIBR We presently show that IFNalpha and dsRNA induce USP18 expression in human islets, primary rat beta cells and INS-1E cells, supporting its role in IFN related signaling pathways and antiviral responses in pancreatic beta cells."
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"Although IL-17A treatment alone didn’t significantly change the expression of USP18, IL-17A pretreatment could further enhance IFN-α-induced expression of USP18."
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