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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

MDM2 bound to MDM4 and TP53 inhibits TP53. 1 / 1
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"In the present study, however, we have uncovered a novel mechanism of p53 inactivation for inducing cisplatin resistance whereby the heterozygous V172F missense mutation in p53 enhances MDM4 recruitment into the p53, MDM2, and MDM4 complex that prevents p53 dependent transcriptional activity and apoptosis."