IndraLab

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USP1 increases the amount of TAp63. 3 / 3
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"In contrast, Usp1 depletion failed to induce TAp63 or p21 expression levels and only slightly induced senescence in Fancd2 (-/-) MEFs."
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"We therefore measured whether USP1 depletion leads to increased TAp63 mRNA levels in human fibroblasts."
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"In wild-type MEFs, Usp1 depletion increased the levels of Fancd2-Ub, TAp63, and p21 (XREF_FIG, lanes 1, 2) and enhanced OIS (XREF_FIG)."
23806336