IndraLab
Statements
rlimsp
"STAT3 and STAT1 activation in HER14 cells was demonstrated to depend on EGF receptor kinase activity, rather than JAK2 activity, while in both K721A and CD126 cells (NIH3T3 transfected with kinase-dead EGF receptor, and EGF receptor lacking major autophosphorylation sites, respectively) STAT1 and STAT3 tyrosine phosphorylation requires JAK2 kinase activity."
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"A77 1726 dose-dependently inhibited total protein tyrosine phosphorylation in uninfected IPEC-DQ (Fig. 4E) and Vero (Fig. 4F) cells.A77 1726 inhibits PEDV replication by inhibiting STAT3 phosphorylation.Yang et al. (2018) reported that PEDV infection of 293T and IPEC-J2 cells rapidly induces STAT3 tyrosine phosphorylation by EGFR tyrosine kinase activation."
| PMC
reach
"A77 1726 dose-dependently inhibited total protein tyrosine phosphorylation in uninfected IPEC-DQ(Fig. 4E)and Vero(Fig. 4F)cells.A77 1726 inhibits PEDV replication by inhibiting STAT3 phosphorylation.Yang et al. (Yang et al., 2018) reported that PEDV infection of 293T and IPEC-J2 cells rapidly induces STAT3 tyrosine phosphorylation by EGFR tyrosine kinase activation."
| PMC
reach
"However, treatment of the SgK223 overexpressing cells with the selective EGFR tyrosine kinase inhibitor erlotinib did not affect Stat3 activation, despite clear inhibition of EGFR Y1068 phosphorylation, indicating that the enhanced Stat3 tyrosine phosphorylation in SgK223 overexpressing cells was not mediated by the EGFR."