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EGF phosphorylates PTK2. 63 / 63
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"Long et al. reported that a splicing isoform of SRC-3, SRC-3Δ4 can mediate Epidermal Growth Factor Receptor (EGFR) and Focal Adhesion Kinase (FAK) interaction, promoting EGF-induced FAK and c-Src phosphorylation and breast cancer cell migration ( xref )."
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"It was observed that expression of WT PKN1 increased TGFbeta1- and EGF dependent phosphorylation of FAK while KN PKN1 expression decreased this effect (XREF_FIG)."
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"Moreover, the results of this study showed that EGF induced FAK phosphorylation in Caco-2 cancer cells, and FAK inhibitors could inhibit EGF-induced FAK phosphorylation in colorectal cancer."
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"In this study, we observed that wild-type PTEN inhibited FAK phosphorylation stimulated by EGF, whereas phosphatase inactive mutant PTEN permitted the induction of FAK phosphorylation."
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"Thus, in rat pancreatic acini the phosphorylation of p125 FAK and paxillin by EGF depends on the integrity of the actin cytoskeleton."
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"EGF, HGF, and IGF-1 stimulate FAK phosphorylation in various cells."
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"Jeong et al. probed that melittin could constrain EGF-induced MMP-9 expression via blocking the NF- κ B and PI3K/Akt/mTOR signaling pathway and repress EGF-induced FAK phosphorylation through inhibiting the mTOR/p/0S6K/4E-BP1 signaling pathway in breast cancer cells [ xref ]."
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"Another finding of our study was the observation that CD73 enhanced invasion and metastasis of HNSCC cells, mediated by activation of EGF and EGFR signaling, and its downstream phosphorylation of FAK."
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"3.5 EBP50 increases EGF-dependent FAK phosphorylation."
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"Moreover, the rapid decrease in the EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation contrasts with previous results showing a sustained increased in p125 FAK and paxillin tyrosine phos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pretreatment with cytochalasin D completely inhibited EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation ( Fig. 10 , top panel lanes 3,4 and bottom panel)."
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"Pretreatment with cetuximab significantly inhibited EGF-induced phosphorylation of Src, FAK, Akt, and ERK1/2 in control cells, but not in Dsg2-depleted cells."
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"EGFR and FAK phosphorylation was also significantly increased by EGF treatment."
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"Although EGF stimulates signal transduction between EGFR and FAK, no evidence for a direct interaction of these two proteins has been observed and it is unclear as to what factor(s) mediates the complex formation between EGFR and FAK and EGF-induced FAK phosphorylation."
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"In contradistinction, apical EGF phosphorylated FAK and MAPKs."
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"It was unclear what factor mediates the interaction between EGFR and FAK and FAK phosphorylation induced by EGF."
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"Here we identify SRC-3Delta4, a splicing isoform of the SRC-3 oncogene, as a signaling adaptor that links EGFR and FAK and promotes EGF induced phosphorylations of FAK and c-Src."
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"In the present study we found that cytochalasin D, which disrupts the integrity of the actin cytoskeleton [38] , completely inhibited EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, while EGF treatment of DAOY cells resulted in increased FAK phosphorylation, ouabain treatment reduced EGF-induced FAK phosphorylation (Fig. xref C) and prevented the formation of EGF-induced actin stress fibers (Fig. xref B)."
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"It is unknown, however, what factor mediates the interaction between EGFR and FAK and leads to EGF-induced FAK phosphorylation."
20159552
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"It was unclear what factor mediates the interaction between EGFR and FAK and FAK phosphorylation induced by EGF."
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"Our results revealed reduced expression of paxillin and decreased phosphorylation of both paxillin and FAK following EGF stimuli in fascin silenced cells."
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"This was established by demonstrating that, after pretreatment of pancreatic acini with thapsigargin in a calcium-free medium to deplete the intracellular calcium stores, EGF-stimulated p125 FAK and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Two recent studies in other tissues [19,20] report that EGF can also stimulate tyrosine phosphorylation of p125 FAK and paxillin, suggesting it could be an important signaling cascade for the EGF r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pretreatment with C3 transferase decreased EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation by 77±13% and 78±35%, respectively ( Fig. 9 , top panel lanes 3,4 and b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGF enhanced FAK phosphorylation and cell spreading in adhering HaCaT cells with low phosphorylated FAK."
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"It was observed that expression of WT PKN1 increased TGFβ1- and EGF-dependent phosphorylation of FAK while KN PKN1 expression decreased this effect ( xref )."
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"Thus, in rat pancreatic acini the phosphorylation of p125 FAK and paxillin by EGF depends on the integrity of the actin cytoskeleton.In summary, we found that EGF causes a rapid, concentration depende[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The above results suggested that EGF induced the phosphorylation of FAK (397 sites) in colorectal cancer cells, and the the downregulated expression or activity of FAK significantly inhibited EGF-induced EMT in colorectal cancer cells.After pretreatment with FAK inhibitor PF-228 (10 μM) for 1 hour, the migration and invasion abilities of EGF-induced colorectal cancer cells was determined by the transwell assay."
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"However, GF109203X pretreatment did not modify EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation ( Fig. 5 A, lanes 3 and 4) or basal tyrosine phosphorylation in con[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pretreatment with wortmannin inhibited EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation in a concentration-dependent manner ( Fig. 6 ) with a half-maximal inhibition occurring with 100 n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, ouabain inhibited EGF-induced activation of the Erk1/2 and Akt signaling pathways as well as p21 Ras activation, prevented EGF-induced formation of actin stress fibers, and inhibited EGF-induced FAK phosphorylation and DAOY cell motility, possibly through activation of stress signaling."
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"This study demonstrated that EGF/EGFR can phosphorylate FAK and induce EMT in colorectal cancer cells.As knowledge of miRNAs continues to grow, more than 1,000 miRNAs have been identified in human gene banks."
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"Furthermore, we found that bee venom suppressed the EMT-related transcription factors ZEB2 and Slug by blocking EGF-induced ERK, FAK and mTOR phosphorylation."
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"EGF enhanced FAK phosphorylation and cell spreading in adhering HaCaT cells with low-phosphorylated FAK."
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"This figure also demonstrates that EGF increases FAK phosphorylation in V7 cells."
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"A recent study identified a splicing isoform of the SRC-3 oncogene, SRC-3Delta4, as a signaling adaptor that links epidermal growth factor receptor (EGFR) and FAK and promotes EGF induced phosphorylations of FAK and c-Src in the signaling cascade leading to epidermal growth factor (EGF)-induced cell migration, an event that requires mechanical signal co-ordination by FA."
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"The above results suggested that EGF induced the phosphorylation of FAK (397 sites) in colorectal cancer cells, and the the downregulated expression or activity of FAK significantly inhibited EGF-induced EMT in colorectal cancer cells."
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"In addition, MEL significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 pathway [ xref ]."
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"In the present study, EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation decreased sharply after 2.5 min, such that at 5 min any increase over the unstimulated control was barely detected."
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"In addition, melittin significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 pathway."
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"This conclusion is supported by the fact that pretreatment of pancreatic acini with two structurally unrelated PI3-kinase activity inhibitors, wortmannin and LY294002, caused a significant reduction i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"SRC-3Delta4 mediates the interaction between EGFR and FAK and augments EGF stimulated FAK and c-Src kinase phosphorylations."
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"To examine the role of the small GTP-binding protein p21 rho in EGF-stimulated p125 FAK and paxillin tyrosine phosphorylation, we used the Clostridium botulinum C3 transferase which specifically i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, melittin significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 pathway."
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"We found that EGF stimulation significantly increased the phosphorylation of Src, FAK, Akt, and ERK1/2 in control cells, but these proteins were not significantly activated in Dsg2 depleted cells."
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"It was unclear what factor mediates the interaction between EGFR and FAK and EGF-induced FAK phosphorylation."
20159552
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"In contrast to the action of a number of neuropeptides in other cell systems, EGF-induced p125 FAK and paxillin tyrosine phosphorylation occurs through a PKC- and calcium-independent mechanism."
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"In addition, FAK phosphorylation in response to EGF varies depending on the tissue type, with some tissues showing no change [21], neither a decrease [40] nor an increase [41,42] in FAK phosphorylatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, an EGF-induced phosphorylation of FAK, yet another essential mediator for cancer cell invasiveness, was markedly inhibited by ENMD-1198 (Fig. xref )."
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"Moreover, pretreatment of pancreatic acini with 100 μM LY294002 for 1 h caused a 49±12% and 47±14% decrease in the tyrosine phosphorylation of p125 FAK and paxillin by EGF (10 nM) ( Fig. 8 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"They also stated that MEL significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E–BP1 pathway."
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"EGF, HGF, and IGF-1 stimulate FAK phosphorylation in various cells."
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"Phosphorylation of FAK was stimulated by aFGF or bFGF, but not significantly by EGF or PDGF."
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"As expected and similar to the effect of SRC-3Δ4 knockdown ( xref ), expression of PAK1KD greatly decreased EGF-stimulated FAK phosphorylation at Y925 ( xref )."
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"In addition, exogenous epidermal growth factor (EGF) treatment increased FAK phosphorylation."
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"This result demonstrated that increases in cytosolic calcium from extracellular stores are also not important for stimulation of p125 FAK and paxillin tyrosine phosphorylation by EGF."
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"In contrast, both adhesion-dependent FAK autophosphorylation ( xref and xref ,) and EGF-stimulated FAK phosphorylation were partly abolished in the Kindlin-1 knockdown group ( xref and xref )."
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"In contrast, EGF or PDGF did not stimulate the tyrosine phosphorylation of FAK."
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"Our results support the conclusion that p21 rho is important for the ability of EGF to stimulate tyrosine phosphorylation in pancreatic acini because C3 transferase pretreatment markedly inhibited EG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The dose–response curves for EGF stimulation of tyrosine phosphorylation of p125 FAK and paxillin were similar to the ability of EGF to cause receptor occupation in rat pancreatic acini [1] , demons[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, knockdown of SRC-3Δ4 in MDA-MB231 cells hindered EGF-induced interaction between EGFR and FAK ( xref ), and greatly decreased EGF-stimulated FAK phosphorylation on Y925 ( xref )."
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"XREF_BIBR Focal adhesion may be regulated by multiple factors, and the results show that PKN1 may interfere with TGFbeta- and EGF dependent phosphorylation of FAK (XREF_FIG)."
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