IndraLab

Statements

USP14 inhibits TARDBP. 3 / 3
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reach
"The DUB USP14 suppresses turnover of Tau and TDP-43 in mouse embryonic fibroblasts (MEFs) by impairing the protea-some; therefore, small-molecule inhibitors of USP14 could help clear these toxic proteins from cells."
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"Previous in vitro studies indicated that either loss of USP14 or inhibition of USP14’s catalytic activity increased the degradation of both model proteasome substrates and over-expressed TARDBP, PRNP, and MAPT proteins in cultured cells (Hanna et al., 2006; Homma et al., 2015; Lee et al., 2010; Lee et al., 2011)."
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"Silencing or inhibiting the proteasomal DUB, USP14 has promoted degradation of ataxin-3, TDP-43 and tau, while increasing expression of proteasomal subunits or identifying small molecule activators of the UPS could also upregulate this rate-limiting step [reviewed in (Kors et al., 2019)]."
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