IndraLab

Statements

USP14 binds α1. 2 / 2
| 2
sparser
"In addition to the loss of Usp14 in mice, we aimed to proof, whether heterologous overexpression of an isolated Usp14 binding site (compare with xref ) of GABA A R α1 would mimic the receptor surface distribution phenotype upon competitive interference with GABA A R α1–Usp14 binding."
19759851
sparser
"Hence, we conclude that the disruption of GABA A R α1-Usp14 binding, and consequently the gene expression knockdown of Usp14 in ax J mice, is directly causal for increased GABA A R surface membrane expression, known to result in enlarged IPSC amplitudes in vivo ."
19759851