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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PPARG bound to RXR activates PPARG. 2 / 2

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"Retinoids, or vitamin A analogs, are among the most promising chemopreventive agents for breast cancer (Table I). Two classes of retinoid receptors, RARand RXR, bind retinoids and mediate transcriptional regulation of genes that control cellular proliferation, differentiation, and apoptosis (52). RXR is able to interact with many other factors such as vitamin D receptor (VDR), peroxisome proliferator- activator receptor (PPAR), thyroid hormone receptor, and COUP (Fig. 1). Retinoids have been shown to inhibit the growth and invasiveness of breast cancer cells in vitro and in vivo ("

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...