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Statements

EIF3F inhibits ribosomal RNA. 2 / 2
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"Mechanistically , the authors found that eIF3f inhibits both cap-dependent and cap-independent translation and that eIF3f promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein K ( Wen et al ., 2012 ) ."
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"Notably , the eIF3f level was reportedly reduced in pancreatic cancer , and overexpression of eIF3f in pancreatic cancer cells resulted in apoptosis ; 33moreover , eIF3f promoted rRNA degradation and inhibited translation.34eIF3f has been shown to act as a tumor suppressor in melanoma.35 ,36 In patients with gastric cancer , reduced expression of eIF3f was associated with poor prognosis , and eIF3f presumably plays an important role in gastric cancer recurrence.37-39However , it remains controversial whether eIF3f acts as an oncogene or a suppressor ."
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