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Nef activates USP15. 6 / 6
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"The above data demonstrated that Nef and USP15 degraded reciprocally and that USP15 mediated degradation of Nef was very pronounced, compared with Nef mediated decay of USP15."
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"Accordingly, USP15 degraded key intracellular viral proteins, such as Nef and Gag in the HIV-1-replicating cells and thereby significantly impaired HIV-1 replication, and Nef induced decay of USP15 which is known to stabilize cellular proteins."
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"Our data showed that as the amount of pHNef was increased from 0 to 4 mug, the USP15 levels gradually decreased in a dose dependent manner without changes to the amount of beta-actin, indicating that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data showed that as the amount of pHNef was increased from 0 to 4 mug, the USP15 levels gradually decreased in a dose dependent manner (XREF_FIG) without changes to the amount of beta-actin (XREF_FIG), indicating that Nef expression caused the intracellular USP15 diminution."
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"Accordingly, USP15 degraded key intracellular viral proteins, such as Nef and Gag in the HIV-1-replicating cells and thereby significantly impaired HIV-1 replication, and Nef induced decay of USP15 wh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, we did not detect significant amounts of USP15 in the nucleus.The above data demonstrated that Nef and USP15 degraded reciprocally and that USP15 mediated degradation of Nef was very pronounc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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