IndraLab

Statements



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"We found that overexpression of CARP significantly inhibited proliferation of BGC-823 cells (XREF_FIG)."

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"Overexpression of C10ORF97 significantly suppressed human lung carcinoma A549 cell growth (proliferation and anchorage independent growth in soft agar) and motility (migration and adhesion)."

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"In the present study, our data showed that elevated CARP expression led to significantly increased apoptosis and decreased proliferation in BGC-823 cells, which suggested that CARP partly inhibits tumor progression via precise regulation of the balance of the cell growth and death."

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"The cell proliferation was significantly inhibited by 1.2-5 folds (P < 0.02) in seven CARP transfected tumor cell lines-lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87."

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"Studies on the biological function of CARP have proved that overexpression of CARP could significantly promote apoptosis in lung carcinoma A549 and human embryonic kidney HEK293s cells, and inhibit cell proliferation in lung carcinoma A549 and PG, melanoma WM451, prostate cancer PC-3 and PC-3M, liver cancer H7402, and bladder cancer BIU87 cells XREF_BIBR, suggesting that CARP is a pro apoptotic protein and has potential anti-tumor effects."

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"We found that over-expression of CARP significantly inhibits proliferation of tumor cell lines examined except two breast cancer cell lines."