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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Heme activates KCNMA1. 2 / 2

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"Native maxi-K + channels recorded in patches excised from glomus cells were activated by HO-2 substrates (heme and NADPH); thus it was proposed that HO-2 acts as an O 2 sensor through the production of CO, which is by itself a maxi-K + channel activator."

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"Soluble guanylyl cyclase (sGC) contains an iron (heme) center that serves to bind NO, however, this site is also targeted by CO, which can activate sGC, leading to increased cytosolic [cGMP], PKG activation and enhanced BK channel activity."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...