IndraLab

Statements

USP14 binds UBE3C. 3 / 3
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"In cells or extracts, adding Usp14 inhibitors (IU-1 or ubiquitin aldehyde) enhanced Usp14 and Ube3c binding further."
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"Then multiple changes occur: this basal inhibition is reversed, more cytosolic Usp14 and Ube3c associate with the 26S particle, and the interaction of the Ub chain with Usp14 (or Uch37) activates the particle's ATPase and proteolytic capacity, all of which favor the selective and efficient degradation of ubiquitylated proteins ( xref )."
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sparser
"For instance, ubiquitinated but not non-ubiquitinated proteins were shown to stimulate association of 26S proteasomes with Usp14 and Ube3c, which in the presence of attached ubiquitin-conjugates induce conformational changes of the proteasome, increase its activity and processivity ( xref ; xref ; xref ; xref )."
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