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databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TP53 binds MDM2 and TAD1. 4 / 4
| 4
sparser
"In this case, the entropic penalty for p53-TAD1 binding to Mdm2, −Δ=+2.2–2.6kcalmol , was much smaller than the value reported herein for binding to MdmX (+8.1±0.1kcalmol; b)."
sparser
"In this case, the entropic penalty for p53-TAD1 binding to Mdm2, -TΔS = +2.2–2.6 kcal mol−1 xref , was much smaller than the value reported herein for binding to MdmX (+8.1 ± 0.1 kcal mol −1 ; xref )."
sparser
"The Mdm2:p53-TAD1 interaction has been the target of drug discovery efforts for more than a decade and compounds with low nM binding constants for the Mdm2 pocket are in clinical trials against a variety of human cancers, some of which are characterized by Mdm2 overexpression xref ."
sparser
"The Mdm2:p53-TAD1 interaction has been the target of drug discovery efforts for more than a decade and compounds with low nanomolar binding constants for the Mdm2 pocket are in clinical trials against[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"