IndraLab

Statements

UCHL5 activates Proteasome. 10 / 10
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"Most of ubiquitinated proteins were accumulated after proteasome inhibition caused by USP14 and UCHL5 inhibition."
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"The inhibition of USP14 and UCHL5 by WP1130 is expected to induce a functional block of proteasome function in cells, but this has not been tested.Eeyarestatin-1 (Eer1) ( Fig. 9 ) was identified in a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The inhibition of UCHL5 and USP14 deubiquitinase activity by WP1130 is expected to block the function of the proteasome in tumor tissue cells, but this still needs to be tested (D'Arcy et al., 2015)."
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"In contrast, Uch37 appears to negatively regulate proteasome-mediated degradation [51] ."
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"The C. elegans homolog of UCHL5, UBH-4, tissue-specifically modulates proteasome activity, also affecting the health and lifespan of these animals [XREF_BIBR]."
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"In a more targeted approach, an active-site ubiquitin probe (HA-Ub-VMS) has been used to demonstrate that USP14/UCHL5 inhibition by a small molecule (b-AP15) inhibits the 19S proteasome in a reconstituted biochemical assay."
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"In addition, the fact that UCH37 activation in the proteasome complex is reversed in the INO80 complex may imply a unique compartmental role or functional partitioning of this enzyme."
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"UCHL5 can suppress proteasome degradation through disassembly of distal polyubiquitin moieties (Lam et al., 1997; Schreiner et al., 2008; Koulich et al., 2008; Jacobson et al., 2009)."
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"In contrast, siRNA of either UCHL5 or USP14 alone did not affect proteasome composition but did increase the rate of proteasome activity, supporting previous studies."
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"Hence, we speculated that Aur inhibited androgen receptor signaling by PKC pathway and promoted the degradation of androgen receptor result from USP14 and UCHL5 inhibition.Interestingly, inhibition of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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