IndraLab

Statements

CYLD ubiquitinates RIPK2. 5 / 5
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reach
"Although depletion of CYLD resulted in extended Ub modifications on RIPK2 (and RIPK1 after TNF treatment), the full extent of regulation of RIPK2 ubiquitination by CYLD (and OTULIN) was uncovered only when we functionally inhibited IAP proteins."
26997266
sparser
"Although depletion of CYLD resulted in extended Ub modifications on RIPK2 (and RIPK1 after TNF treatment), the full extent of regulation of RIPK2 ubiquitination by CYLD (and OTULIN) was uncovered only when we functionally inhibited IAP proteins."
26997266
sparser
"This suggests that the regulation of RIPK2 ubiquitination by CYLD (and LUBAC and OTULIN) could influence the response to infection by intracellular bacteria."
26997266
reach
"Remarkably, depletion of CYLD under these conditions restored RIPK2 ubiquitination to comparable levels as in NOD2 stimulated cells not treated with CpA (XREF_FIG A, compare lane 8 with lanes 3 and 7)."
26997266
reach
"This suggests that the regulation of RIPK2 ubiquitination by CYLD (and LUBAC and OTULIN) could influence the response to infection by intracellular bacteria."
26997266