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EGFR binds SOS and GRB2. 21 / 21
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"The measurable catalytic exchange activity of Sos in immunocomplex is unaltered by the association of Sos with EGF receptor and Grb2, either when the association occurs in EGF- stimulated cells or by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8490966
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"Upon EGFstimulation of the cell, binding of Sos to the EGF receptor-Grb2 complex brings a significant portion of Sos to the membrane (Figure 5)."
8490966
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"In rat-1 cells the only tyrosine phosphorylation event observed in the formation of the EGF receptor-Grb2-Sos complex is the autophosphorylation of the EGF receptor."
8490966
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"The association of Sos with Grb2 and EGF receptor is effectively blocked by low concentrations of a phosphotyrosine-containing peptide based on the sequence of the EGF receptor around Y1068, one of it[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8490966
sparser
"The Grb2-Sos complex binds to the EGF receptor, thus recruiting SOSto the plasma membrane where Ras is located (Fig. 3a)."
15335710
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"Zhang and Lautar [29'] used as an example the Grb2-mediated interaction of the cytoplasmic domain of the epidermal growth factor receptor with the Sos protein."
9353226
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"This should enhance ERK1/2 signaling via Grb2 and SOS interactions with phosphorylated EGFR, but ERK1/2 activation was not examined in this report[ xref ]."
20815659
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"EGF treatment of cells promotes the formation of a complex of EGF receptor, Grb2, and Sos."
8490966
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"Following EGFR activation, Grb2 and Sos (adaptor proteins) bind EGFR directly at Y1092 and Y1110 or through Shc (which binds at EGFR Y1172 and Y1197) [ xref ]."
18778701
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"We only considered this effect for the assembly of the EGFR, Grb2, and Sos complex, but other components of the EGRF signaling network may also decrease their mobility upon activation."
14695245
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"Another difference between the two pathways is that EGF and NGF utilize different signal transduction pathways to stimulate RasGTP: the Grb2-Sos complex is directly bound to the EGF receptor, wher[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7834738
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"In contrast to the activated epidermal growth factor receptor that binds the GRB2-Sos complex directly, activation of the insulin receptor results in the interaction of GRB2-Sos with IRS-1 and Shc, thus linking the insulin receptor to Ras signaling pathways."
8316835
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"If the stimulation of exchange activity measured in this permeabilized cell system was due to the formation of EGF receptor-Grb2-Sos complexes, then it may be possible to inhibit it by the use of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8490966
sparser
"In response to epidermal growth factor (EGF), the activated EGF receptor binds to a complex containing the signaling protein GRB2 and the Ras guanine nucleotide-releasing factor Sos, leading to activation of the Ras signaling pathway."
8264620
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"In rat-1 cells the only tyrosine phosphorylation event observed in the formation of the EGF receptor, Grb2, and Sos complex is the autophosphorylation of the EGF receptor."
8490966
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"Zhang used this system to demonstrate the Grb2-mediated interaction of the cytoplasmic domain of the epidermal growth factor receptor with the Sos protein."
12734586
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"As expected, mutation of the Grb2 binding site significantly reduced the interaction of Grb2 and SOS with EGFR ( xref )."
23027125
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"The binding of the Grb2 adaptor protein and the associated SOS protein (a Ras Guanine nucleotide Exchange Factor) to the EGFR results in the activation of the membrane associated Ras GTPase, and subsequently activation of the MAPK cascade consisting of Raf, MAPK/ERK Kinase (MEK) and Extracellular Regulated Kinase (ERK) xref ."
22558469
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"We only considered this effect for the assembly of the EGFR-Grb2-Sos complex, but other components of the EGRF signaling network may also decrease their mobility upon activation."
14695245
sparser
"Using epidermal growth factor (EGF) receptor, Grb2 and Sos proteins as an example, we demonstrated the use of the three-hybrid system to detect formation of a three-component complex, i.e., the Grb2-mediated interactions between EGF receptor and Sos."
8923966
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"In healthy cells, pEGFR-SH2 specific binding forms the EGFR/GRB2/SOS complex that activates the Ras/MAPK pathway."
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