IndraLab
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"The binding of the Grb2 adaptor protein and the associated SOS protein (a Ras Guanine nucleotide Exchange Factor) to the EGFR results in the activation of the membrane associated Ras GTPase, and subsequently activation of the MAPK cascade consisting of Raf, MAPK/ERK Kinase (MEK) and Extracellular Regulated Kinase (ERK) xref ."