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USP8 inhibits accumulation Cx43. 1 / 1

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"Thus , we propose that , in the absence of AMSH , ubiquitinated Cx43 is mainly directed to degradation , while lack of USP8 results in the accumulation of Cx43 , likely at late endosomes / MVBs , modified with ubiquitin chains that favor its sorting into ILVs that will be subsequently secreted as EVs ( Bejarano et al , 2012 ; Martins-Marques et al , 2015c ) ."

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IndraLab

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USP8 inhibits accumulation Cx43. 1 / 1

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