IndraLab

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USP9X increases the amount of MCL1. 22 / 22
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"We also observed that Usp9x KD decreased Mcl-1 levels in MIAPACA2 cells but increased Mcl-1 levels in 8041 cells."
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"While Usp9X is known to modulate Mcl-1 expression, our observed effects of Usp9X manipulation on Bag3 and Bcl-2 have not been previously described and may suggest that Usp9X also interacts with Bag3 as well as Bcl-2."
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"WP1130 is an inhibitor of USP9x, which is known to upregulate the level of Mcl-1, leading to apoptosis."
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"Usp9X modulates Mcl-1 levels and counteracts apoptosis in cancer cells [XREF_BIBR]."
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"Knockdown of the de-ubiquitinase Usp9x of MCL1 can decrease the protein level of MCL1 and increase the sensitivity of colon carcinoma and leukemia cells to ABT-737 [ 55 ]."
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"Furthermore, knockdown of Usp9X or Bag3 depleted endogenous Mcl-1 protein levels and in turn enhanced apoptosis induced through Bcl-2 and Bcl-xL inhibition [XREF_BIBR]."
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"In line with these observations, MCL1 protein levels were downregulated by depletion of USP9X but not USP13 (Figure S6D)."
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"The decreased expression of USP9X subsequently reduced Mcl-1 expression and increased Bax expression, which may be the cause of apoptosis in laryngeal cancer cells."
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"We have shown previously that USP9X inhibition by WP1130 reduces MCL-1 levels, promotes apoptosis and increases tumor cell sensitivity to chemotherapy [XREF_BIBR]."
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"USP9X positively promotes the expression of Mcl-1."
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"Inhibition of USP9X and USP24 increases the ubiquitination of MCL-1 and decreases the level of MCL-1."
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"XREF_BIBR More recently, in non small cell lung carcinoma, inhibition of USP9X by either siRNA knockdown or via a small molecule inhibitor WP1130 decreased MCL1 expression and sensitized cells to radiation therapy."
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"Indeed, USP9X knockdown decreases the level of MCL1 protein, sensitizes MCL1-resistant colon carcinoma and leukemia cells to ABT-737 , and sensitizes radioresistant cells to apoptosis induction ."
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"Based on our previously published observation that Usp9X induces a decline of Mcl-1 protein levels in GBM cells , we hypothesized that similar effects would be observed in MPNST cells."
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"Moreover, examination of Mcl-1 levels 48 h after irradiation with 0 Gy and 10 Gy revealed that USP9x knockdown prevented the radiation-induced increase of Mcl-1 levels in LNCaP cells, while only minor effects of USP9x knockdown on MCL-1 levels were detected in irradiated PC3 cells (Figure 6F)."
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"Finally, we demonstrated that a knockdown of USP9x reduced Mcl-1 levels and sensitized particularly LNCaP cells to radiotherapy.Our findings suggest that deubiquitinase USP9x is responsible for upregulated Mcl-1 protein levels, thereby contributing to prostate cancer progression and therapy resistance."
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"USP9x-mediated stabilization of Mcl-1 protein levels by preventing its degradation was described before as a mechanism that increased apoptosis threshold in other tumor entities [22,33]."
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"Mechanistically, Usp9X knockdown caused concomitant suppression of Bag3, Mcl-1 and Bcl-2 expression, which remarkably recapitulates the effects of CP-d and n-ATF 5-S1 on these molecules."
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"Thus, EOAI3402143, an inhibitor of the deubiquitinases Usp9x and Usp24, reduced Mcl-1 protein levels in MM cells and lowered disease burden in an animal model of MM [98]."
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"These ITCs increased Mcl-1 ubiquitination and either ITC treatment or RNAi mediated silencing of USP9x decreased Mcl-1 levels, consistent with the notion that USP9x is a primary target of ITC activity."
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"Similar distinction was also observed for Mcl-1, one observed substrate of Usp9x, where Usp9x KD increased Mcl-1 levels in 8041 cells but decreased Mcl-1 in MIAPACA2 cells."
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"In addition, the blocking of USP9X activities using a small-molecule inhibitor decreases Mcl-1 expression by promoting its degradation and thus sensitizes tumor cells to chemotherapeutic agents."
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