IndraLab

Statements

CACNA1A activates NAV1. 7 / 7
| 7
sparser
"While the voltage-dependent activation of Nav1.5 or Nav1.7 was not affected by mexiletine and lidocaine, the steady-state fast and slow inactivation of Nav1.5 and Nav1.7 were significantly shifted to hyperpolarized direction by either mexiletine or lidocaine in dose-dependent manner."
26068619
sparser
"In this study, the effects of BmK AS, a sodium channel-specific modulator from Chinese scorpion Buthus martensi Karsch, on the voltage-dependent activation and inactivation of Nav1.2 were examined before and after PKA activation."
24430351
sparser
"Navβ2 causes a depolarizing shift in Nav1.1 and Nav1.6 (encoded by SCN8A ) voltage dependent activation and inactivation [ xref , xref ]."
29245901
sparser
"However, the voltage-dependent activation of Nav1.8 in neurons treated with PBS (V 1/2  = −10.2 ± 0.1 mV; slope k  = 5.1 ± 0.1 mV) was not significantly different from that with CXCL13 at 10 ng/ml (V 1/2  = −9.3 ± 0.2 mV; k  = 3.9 ± 0.2 m."
27708397
sparser
"Whole cell patch studies revealed little change in voltage dependent activation and deactivation of Nav1.9, but significant increases in the amplitude of Nav1.9 were observed 8weeks after exposure."
24732443
sparser
"The influence of permethrin on AP duration, after hyperpolarization, spontaneous activity, half-activation potential (V1/2) and taudeact were reduced, but not fully reversed, when tests were conducted at 35 °C. In conclusion, permethrin greatly modifies the voltage dependent activation and deactivation of Nav1.8 expressed in skin, muscle and vascular nociceptors."
23701970
sparser
"G(V) relationship indicated that BmK I shifted voltage-dependent activation of Nav1.8 in a hyperpolarizing direction (Fig.  xref A)."
25903152