IndraLab

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DNMT1 methylates TP53. 4 / 4
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"Here we show that in response to extensive hepatocyte damages, expression of dnmt1 is upregulated in BECs to methylate DNA at the p53 locus, which represses p53 transcription, and in turn, derepresses mTORC1 signaling to activate BEC dedifferentiation."
35351894
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"Similarly, bisulfite sequencing analysis confirmed in HDFs that UVA irradiation caused demethylation of CpG in the p53 promoter region, while DNMT1 up-regulation could methylate CpG islands of p53, although the demethylation caused by UVA and DNMT1 induced methylation did not occurred at the same CpG islands (XREF_FIG)."
29466247
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"We present, for the first time, direct evidence that DNMT1 modulates p53 methylation; furthermore, we precisely identify the sites of methylation within the p53promoter that are affected during UVA induced senescence."
29466247
reach
"Bisulphite sequencing analysis indicated that DNMT1 and DNMT3beta did not cause p53 promoter hypermethylation."
27488808