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DNMT1 methylates TP53. 15 / 15
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"In addition, DNMT1 increases the DNA methylation of TP53 and decreases p53 expression [ xref , xref ]."
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"Georgia et al. found that one of the DNA methyltransferases, Dnmt1, methylates the p53 locus in PPCs to inhibit apoptosis."
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"Subsequently, the hyperactivation of IL-6 induces the overexpression of DNMT1, which, in turn, methylates the promoter of the p53 gene by initiating IL-6\p53\DNMT1 autocrine loop (Hodge et al., 2005; D'Anello et al., 2010; Liu et al., 2015)."
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"In this study, we found that estrogen-induced DNMT1 increased the DNA methylation of TP53 to repress p53 expression, which positively affected DNMT1 expression, thus promoting poor prognosis of lung cancer by modulating EMT and the microenvironment."
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"Here we show that in response to extensive hepatocyte damages, expression of dnmt1 is upregulated in BECs to methylate DNA at the p53 locus, which represses p53 transcription, and in turn, derepresses mTORC1 signaling to activate BEC dedifferentiation."
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"Bisulphite sequencing analysis indicated that DNMT1 and DNMT3beta did not cause p53 promoter hypermethylation."
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"We present, for the first time, direct evidence that DNMT1 modulates p53 methylation; furthermore, we precisely identify the sites of methylation within the p53promoter that are affected during UVA induced senescence."
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"In addition, DNMT1 increases the DNA methylation of TP53 and decreases p53 expression [22, 23]."
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"Similarly, bisulfite sequencing analysis confirmed in HDFs that UVA irradiation caused demethylation of CpG in the p53 promoter region, while DNMT1 up-regulation could methylate CpG islands of p53, although the demethylation caused by UVA and DNMT1 induced methylation did not occurred at the same CpG islands (XREF_FIG)."
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"A previous study indicated that DNMT1 could methylate the promoter of TP53 to inhibit its expression [34, 54]."
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"This study presents novel findings on the association between the methylation of the p53 pathway (BAX/P53/CASPASE-6/BCL-2) mediated by methyltransferase (G9aMT/DNMT1) and the outcome (continuation or cessation) of early pregnancy [116]."
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"These findings further strengthen our suggestion that p53 serves as a negative regulator on DNMT1 gene transcription, which in turn modulates Syk gene methylation and expression.2.4 p53 also positivel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we found that estrogen-induced DNMT1 increased the DNA methylation of TP53 to repress p53 expression, which positively affected DNMT1 expression, thus promoting poor prognosis of lung cancer by modulating EMT and the microenvironment."
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"E2-induced DNMT1 expression increases DNA methylation of p53 to inhibit its transcriptional activity."
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"In human multiple melanoma cell U266, berberine can inhibit the expression of DNMT1 and DNMT3B, which leads to hypomethylation of TP53 by altering the DNA methylation level and the p53-dependent signal pathway."
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