IndraLab

Statements

USP28 inhibits MAPK. 6 / 6
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"It has been reported that loss of USP28 stabilizes BRAF and enhances MAPK pathway activity, and eventually promotes resistance to BRAF inhibitors in melanoma cells."
35760282
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"Collectively our results show that loss of USP28 enhances downstream MAPK activation through the stabilization of BRAF, leading to decreased sensitivity to combination therapies involving BRAF inhibitors dabrafenib or vemurafenib (XREF_FIG)."
29880484
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"Importantly, of the 59 patients harboring BRAF V600E mutations 27% (16/59) displayed a> 50% decrease in USP28 mRNA expression levels, suggesting that in tumors harboring BRAF alterations, loss of USP28 may further increase the tumorigenic potential of these tumors by stabilizing BRAF and enhancing downstream MAPK activation."
29880484
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"XREF_BIBR In a proportion of melanoma patients, USP28 was deleted, and loss of USP28 enhanced MAPK activity through the stabilization of RAF family members, which suggested that USP28 was a key factor in BRAF inhibitor resistance."
30881015
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"The loss of USP28 promoted MAPK activation and resistance to RAF inhibitor therapy by stabilizing BRAF in cell culture and in vivo models."
31938050
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"This confirms that loss-of-function mutations in USP28 can induce MAPK pathway activation by stimulating the fibrosarcoma-ERK pathway."
38790424