IndraLab

Statements

USP10 binds AR. 14 / 18
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biogrid
No evidence text available
16368182
sparser
"In order to determine whether the interaction of USP10 with the AR affected its transcriptional function, a construct for transient expression was devised in the pSG5 plasmid."
16368182
sparser
"Moreover, USP10 not only binds AR, resulting in increased transcriptional activity, but also deubiquitinates the histone variant H2A.Z, both of which are required for AR − mediated gene activation [ xref , xref ]."
29353883
reach
"USP10 was originally detected in DNA bound AR complexes but the results of GST pull-down experiments indicate that USP10 may interact with the AR also in absence of response elements, at least when us[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16368182
biogrid
No evidence text available
16368182
sparser
"USP10 was originally detected in DNA-bound AR complexes but the results of GST pull-down experiments indicate that USP10 may interact with the AR also in absence of response elements, at least when us[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16368182
reach
"The difference in migration was probably due to post-translational modifications.In order to further analyse the interaction between USP10 and the AR, GST pull-down experiments were performed."
16368182
sparser
"In order to further analyse the interaction between USP10 and the AR, GST pull-down experiments were performed."
16368182
reach
"Usp10 can bind to AR and positively regulate its transcriptional activity [XREF_BIBR] however, it also regulates AR indirectly via deubiquitination of H2A.Z causing the same effect [XREF_BIBR]."
25216524
sparser
"Our data suggest that if USP10 and AR do physically interact, this interaction only occurs in a small nuclear fraction of USP10."
21245042
sparser
"The results show that significantly more AR was retained in the presence of USP10-GST as compared to GST alone, documenting that USP10 and the AR interacted with each other."
16368182
sparser
"The interaction between USP10 and the AR was confirmed by GST pull-down assays."
16368182
reach
"The interaction between USP10 and the AR was confirmed by GST pull-down assays."
16368182
sparser
"Usp10 can bind to AR and positively regulate its transcriptional activity [ xref ] however, it also regulates AR indirectly via deubiquitination of H2A.Z causing the same effect [ xref ]."
25216524