IndraLab

Statements

ANK3 binds KCNQ2. 19 / 19
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"By identifying the causally related variants, will be able to examine in in vivo and in vitro models the mechanisms by which they disrupt the interactions between ANK3 and KCNQ2 and contribute to the molecular underpinnings of BP."
23730306
sparser
"We have shown that fusion of the KCNQ2 C-terminal tail was sufficient to enrich CD4 at the axonal surface ( xref – xref ) regardless of KCNQ2 binding to ankyrin-G ( xref )."
25077630
sparser
"The interactions between ANK3 and KCNQ2 merit further investigation, and if confirmed, may motivate a new line of research into a novel therapeutic target for BP."
23730306
sparser
"We found compelling biological evidence for interactions between ANK3 and KCNQ2 based on a bioinformatics search using STRING, and observed congruent statistical evidence of interactions between these genes in association with BP using GWAS data."
23730306
sparser
"Despite the biological and statistical evidence reported here in support of a role for interactions between ANK3 and KCNQ2 in the etio-pathogenesis of BP, there are several limitations of the study that merit consideration."
23730306
sparser
"By identifying the causally related variants, will be able to examine in in vivo and in vitro models the mechanisms by which they disrupt the interactions between ANK3 and KCNQ2 and contribute to the molecular underpinnings of BP."
23730306
sparser
"We have found intriguing evidence that interactions of ANK3 with KCNQ2 may contribute to susceptibility for BP."
23730306
sparser
"If the interactions of ANK3 with KCNQ2 can be confirmed to play a role in the etio-pathogenesis of BP, it would motivate a new avenue of research into a novel therapeutic target for this disease."
23730306
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"One additional study showed that the interaction of potassium channel genes ANK3 and KCNQ2 were also related to bipolar disorder (Judy et al., 2013)."
37161899
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"Ankyrin-G additionally interacts with potassium channels Kv7.2 (KCNQ2) and Kv7.3 (KCNQ3) via a conserved stretch of 10 amino acids, which is similar to the ankyrin-G-binding sequence in Nav1 channels ."
35794211
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"Moreover, the CK2 inhibitors TBB and TBCA have been used to study the interaction between ankyrin G and KCNQ2 and it was demonstrated that inhibition of CK2 kinase activity results in a reduced interaction of ankyrin G with KCNQ2 ( xref ) ( xref , xref , xref )."
33082952
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"Moreover, a different study found an epistatic interaction between ANK3 and KCNQ2 SNPs in bipolar disorder, i.e. the effect of a mutation in one gene was dependent on the mutation present in the other gene [ xref ]."
24913350
reach
"We found compelling biological evidence for interactions between ANK3 and KCNQ2 based on a bioinformatics search using STRING, and observed congruent statistical evidence of interactions between these genes in association with BP using GWAS data."
23730306
reach
"In line with this role, ANK3 interacts directly with KCNQ2, which is expressed in the brain and forms homomeric and heteromeric voltage gated potassium channels with another member of the KCNQ family, KCNQ3."
23730306
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"Furthermore, the E810A and D812A mutations in KCNQ2 C-terminus, which disrupt ankyrin-G binding to KCNQ2 XREF_BIBR, XREF_BIBR, XREF_BIBR, reduced the surface " AIS and Axon " ratio of CD4-Q2C to 1, but had no effect on the surface " Axon and Dendrite " ratio (XREF_SUPPLEMENTARY)."
25077630
sparser
"While none were significant in the second replication sample, the two discovery KCNQ2 SNPs showed significant interactions with five different ANK3 SNPs, supporting potential allelic heterogeneity."
25964797
reach
"We have shown that fusion of the KCNQ2 C-terminal tail was sufficient to enrich CD4 at the axonal surface (XREF_FIG - XREF_FIG) regardless of KCNQ2 binding to ankyrin-G (XREF_SUPPLEMENTARY)."
25077630
reach
"The interactions between ANK3 and KCNQ2 merit further investigation, and if confirmed, may motivate a new line of research into a novel therapeutic target for BP."
23730306
reach
"Despite the biological and statistical evidence reported here in support of a role for interactions between ANK3 and KCNQ2 in the etio-pathogenesis of BP, there are several limitations of the study that merit consideration."
23730306