IndraLab
Statements
reach
"Mdm2 can also drive the degradation of mutant p53, which indicates that the mutant p53 proteins are not intrinsically resistant to Mdm2 associated degradation, although in tumor cells this regulation is disrupted because p53 dependent transcription of Mdm2 is inhibited by the loss-of-function of mutant p53 or by the dominant negative effect of mutant p53 over WT p53 [XREF_BIBR]."
reach
"We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53 deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription independent mechanism."