IndraLab

Statements

OTULIN binds LUBAC. 6 / 6
| 1 5
reach
"Upon TNFalpha stimulation, the TNF-R1 was enriched in SHARPIN IPs (XREF_FIG E), further supporting the idea that a LUBAC and OTULIN complex is formed and that this complex may translocate to the TNF receptor signaling complex (TNF-RSC)."
23746843
reach
"We show that OTULIN binds LUBAC and that overexpression of OTULIN prevents TNFalpha induced NEMO association with ubiquitinated RIPK1."
23746843
reach
"Indeed, as discussed below, LUBAC and OTULIN form a complex and their activities are likely to be interdependent."
26503766
trips
"OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin."
34157307
reach
"Moreover, immunoprecipitation of SHARPIN copurified HOIP, HOIL-1 and OTULIN, and OTULIN interacted with HOIP in proteomic experiments, indicating that OTULIN may associate with HOIP and/or LUBAC."
24726323
reach
"Moreover, LUBAC and OTULIN complex formation is regulated by OTULIN phosphorylation in the PIM."
24726323