IndraLab

Statements

JNK decreases the amount of IRS1. 5 / 5
1 | 4
signor
"Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylationOne of the specific Ser phosphorylation sites in IRS-1 that has been proposed to negatively modulate the insulin signal is Ser312 (numbered according to the human sequence). Prior studies have demonstrated that IRS-1 associates with and is phosphorylated by JNK in vitro on Ser312"
12510059
reach
"To our knowledge, this is the first study to show that increased JNK activation can lead to decreased IRS-1 protein levels, presumably via IRS-1 ubiquitination mediated via serine phosphorylation of this protein."
22832498
reach
"Moreover, selective JNK inhibition with JNK-IN-8 or p38 inhibition with SB203580 attenuated the nicotine dependent phosphorylation of Irs1-Ser307 and the subsequent reduction of Irs1 protein expression (XREF_SUPPLEMENTARY)."
25799226
reach
"Combined with the fact that PP4 can not only activate JNK to induce the phosphorylation of IRS-1 on serine 307, but reduce the expression of IRS-1, we believe that PP4 formed a complex with IRS-1 to promote the phosphorylation of IRS-1 via JNK activation as well as reduce the expression of IRS-1."
26666849
reach
"Additionally, JNK expression ( p = 0.0093) was upregulated with coinciding increases in p-IRS1 protein expression ( p < 0.0001) and decreased IRS1 mRNA expression ( p = 0.0004)."
37047241