IndraLab

Statements

PKA activates KCNMA1. 11 / 12
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"In addition, in presence of this subunit, PKA modulation of the BK channel is not necessary for potentiation by alcohol."
27238266
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"Currents of BK channels decreased in coronary artery smooth muscle cells, and PKA modulated BK channel functions were declined."
28133948
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"PKA activity can either increase or decrease BK channel activity depending on the splice isoform of BK."
19342611
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"Together, these data suggest that PKA increases BK channel activity that is dependent on intracellular Ca concentration and that hair cells have a basal level of PKA activity.3."
32748549
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"Pharmacological inhibition of the constitutive PKA activity with H-89 or PKI 14-22 significantly reduced the frequency and amplitude of spontaneous transient BK channel currents (TBKCs) in UBSM cells."
25318105
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"It has been shown that PKA mediated phosphorylation of the SK2 channel subunit significantly decreases membrane SK2 channels and SK channel function, whereas BK channel activity is augmented by PKA."
29511121
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"Lastly, PKA can increase BK channel activity via direct channel phosphorylation."
24744252
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"PKA can both activate and inhibit BK channel opening, depending on the splice variant of the channel [XREF_BIBR - XREF_BIBR]."
23376354
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"A PKA dependent mechanism may underlie acute tolerance of the BK channel while rapid or chronic tolerance appears to be mediated through a miRNA dependent mechanism which alters the splice variant composition and therefore alcohol sensitivity of the channel."
23889059
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"BK channel activation by PKA catalytic subunit in rat colonocytes."
19407217
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"Pooled data from 10 patches (XREF_FIG) indicated that the PKA catalytic subunit stimulated BK channel activity after 5 min, although the increase in P o from a basal level of 0.37 +/- 0.11 was only significant after 10 min (to 0.64 +/- 0.08, P < 0.05) and remained so after 15 min."
19407217