IndraLab

Statements

PKA activates KCNMA1. 15 / 16
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"Physiologically, activation of Slo by PKA would produce muscle quiescence; whereas inhibition would favor muscle contraction."
16102753
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"Pharmacological inhibition of the constitutive PKA activity with H-89 or PKI 14-22 significantly reduced the frequency and amplitude of spontaneous transient BK channel currents (TBKCs) in UBSM cells."
25318105
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"BK channel activation by PKA catalytic subunit in rat colonocytes."
19407217
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"Pooled data from 10 patches (XREF_FIG) indicated that the PKA catalytic subunit stimulated BK channel activity after 5 min, although the increase in P o from a basal level of 0.37 +/- 0.11 was only significant after 10 min (to 0.64 +/- 0.08, P < 0.05) and remained so after 15 min."
19407217
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"Lastly, PKA can increase BK channel activity via direct channel phosphorylation."
24744252
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"As demonstrated for the tail artery [47] and discussed in detail in [16,68], the molecular characteristics of the stimulation of the BK channel by the AC pathway (e.g., requirement for cAMP and MgATP, role of phosphatases, features of the interaction with PKA inhibitors) strongly suggest that phosphorylation of the channel underlies the PKA-induced stimulation of the BK channel."
39000253
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"PKA can both activate and inhibit BK channel opening, depending on the splice variant of the channel [XREF_BIBR - XREF_BIBR]."
23376354
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"Subsequebntly, 1 year later, Velázquez-Marrero et al (110) showed that the β4 subunit affects the way PKA and PKC modulate the BK channel activity in the presence of alcohol."
40236633
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"PKA activity can either increase or decrease BK channel activity depending on the splice isoform of BK."
19342611
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"It has been shown that PKA mediated phosphorylation of the SK2 channel subunit significantly decreases membrane SK2 channels and SK channel function, whereas BK channel activity is augmented by PKA."
29511121
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"Together, these data suggest that PKA increases BK channel activity that is dependent on intracellular Ca concentration and that hair cells have a basal level of PKA activity.3."
32748549
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"In addition, in presence of this subunit, PKA modulation of the BK channel is not necessary for potentiation by alcohol."
27238266
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"A PKA dependent mechanism may underlie acute tolerance of the BK channel while rapid or chronic tolerance appears to be mediated through a miRNA dependent mechanism which alters the splice variant composition and therefore alcohol sensitivity of the channel."
23889059
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"Currents of BK channels decreased in coronary artery smooth muscle cells, and PKA modulated BK channel functions were declined."
28133948
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"Physiologically, activation of Slo by PKA would produce muscle quiescence; whereas inhibition would favor muscle contraction."
16102753